Daikin Industries, Ltd.

Shionogi Company Limited

The University of Tokyo

Tohoku University

Manabu Katou

Masahiko Chouji

Kaichi Tsuji

Kentarou Niki

Kouichirou Seki

Hiroko Kashimoto

Junji Nakamura

Dai Satou

Yuuichi Murai

Yumi Ohta

Toshiyuki Nishio

Nobuyuki Tanaka

Masafumi Iwatsu

Eiichi Kojima

Naoki Ohyabu

Toshihiro Wada

Masahiko Fujioka

Akira Ino

Keisuke Tonogaki

Koji Masuda

Naoki Yoshikawa

Shiro Kida

Yoshikazu Sasaki

Yusuke Tateno

Yuji Nishiura

Yu Hinata

Keisuke Miyazaki

Kana Kurahashi

Mado Nakajima

Tetsuo Nagano

Akira Kugimiya

Hirotatsu Kojima

Osamu Nureki

Naotake Kobayashi

Hiroshi Nishimasu

Takayoshi Okabe

Ryuichiro Ishitani

Chiaki Fujikoshi

Takatsugu Inoue

Terukazu Kato

Junken Aoki

Yutaka Tomida

Kyohei Hayashi

Mitsuyasu Kawaguchi

Mitsuhiro Yonehara

Junji Yamane

Masataka Fumoto

Masahide Odan

Kentarou Asahi

Masahide Ohdan

Tomomi Urabe

Kouji Masuda

The present invention provides a compound represented by a following formula. A compound represented by, wherein

Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity

The purpose of the present invention is to provide novel compounds having ACC2 selective inhibitory activity. In addition, the present invention provides a pharmaceutical composition comprising the compound. A compound of Formula:  

9-membered fused ring derivative

The present invention provides a compound of formula (1), wherein R, R, R, R, R, Rand Rare as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound. 

Fused pyrazole derivative having autotaxin inhibitory activity

The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. A compound of formula (I): 

Alkylene derivatives

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof,

Azabenzimidazole derivative having AMPK-activating activity

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: 

Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula:   

Hetero ring-fused imidazole derivative having AMPK activating effect

Disclosed is a compound which is useful as an endothelial lipase inhibitor. A pharmaceutical composition having inhibitory activity on endothelial lipase comprising a compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof,wherein

Acetic acid amide derivative having inhibitory activity on endothelial lipase

A compound represented by the formula: or its pharmaceutically acceptable salt. Ring A is aromatic carbocycle or aromatic heterocycle, Z is &#x2014;O&#x2014; or &#x2014;S&#x2014;, Ris hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, Rand Rare each independently hydrogen, halogen, hydroxy or the like, Ris a group represented by the formula: &#x2014;(CRR)&#x2014;R, Rand Rare each independently hydrogen, halogen, hydroxy or the like, n is an integer of 0 to 3, Ris carboxy, cyano, substituted or unsubstituted alkyl or the like, Ris halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, and m is an integer of 0 to 3.

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Osaka, Japan

Manabu Katou