Shibakai Co., Ltd.

Chugai Seiyaku Kabushiki Kaisha

National Center of Neurology and Psychiatry

Manabu Araki

Toru Araki

Takashi Yamamura

Takako Matsuoka

It has become clear that the therapeutic effect of an IL-6 inhibitor for IL-6- and neutrophil-associated diseases can be predicted using the expression level of neutrophil-associated genes as an indicator. It has also become clear that an IL-6 inhibitor is effective for the treatment of IL-6- and neutrophil-associated diseases in patients with high expression levels of neutrophil-associated genes. The present invention provides a method for selecting cases of IL-6- and neutrophil-associated diseases in which treatment with an IL-6 inhibitor is effective, as well as a method for effectively treating patients with IL-6- and neutrophil-associated diseases and with high expression levels of neutrophil-associated genes.

Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils

To avoid or reduce the necessity of loading a cargo container on a container carrying vehicle, for example, a cargo containerincludes: engaging portionsdisposed at four corners of each of upper and lower surfaces of a shelland each engageable with a spreader of a container crane; and a wheelcapable of supporting the cargo containersuch that the cargo containeris allowed to run. The wheelis switchable between a runnable state where at least a lowermost portion is located below a bottom surfaceof the cargo containerand supports the cargo containersuch that the cargo containeris allowed to run, and a loaded state where the wheelmoves inward from the bottom surfaceand the bottom surfaceis allowed to make contact with a mount surface of the cargo container

Cargo container

A method of handling bulk cargo, including suspending, with a spreader of a container crane, a cargo handling system above a dock where a ship loaded with bulk cargo lands, the cargo handling system including a frame having an engaging portion engageable with the spreader of the container crane, a blower attached to the frame and configured to suck air, and a separator attached to the frame and configured to separate bulk cargo sucked along with the air from the air sucked by the blower. While the cargo handling system is suspended above the dock, using the cargo handling system to suck up the bulk cargo from the ship with the blower of the cargo handling system together with the air; separate the bulk cargo from the air with the separator of the cargo handling system; and discharge the separated bulk cargo from the cargo handling system.

Cargo handling method

The availability of a container crane or a dock is improved. A cargo handling method includes steps of: moving a lighterto a different dock, the lightercarrying a freight container wheeled platformloaded on the lighterthe freight container wheeled platformcarrying a containerplaced on the freight container wheeled platformin a container yard; and unloading the freight container wheeled platformfrom the lighterto the different dock.

To be able to improve the flexibility in handling containers, a container ship configured to transport containers includes: an openingthrough which cargo may be handled by moving a wheeled platformbetween the container ship and a dock, the wheeled platformincluding a plurality of containersplaced thereon; and a floor boardor a rail configured to support the wheeled platformloaded from the dock through the opening

Growing community of inventors

Tokyo, Japan

Manabu Araki