The University of Hong Kong

Vision Global Holdings Limited

Man-Kin Wong

Dan Yang

Chi-Ming Che

Norman Fung-Man Wai

Sui-Yi Kwok

Yiu-Chung Yip

Jian-Hua Zhang

Benjamin Chi-Yin Wai

Man-Wai Tang

Provided herein are mertansine polypeptide conjugates useful in the treatment of cancer, pharmaceutical compositions comprising the same, and methods of use and preparation thereof. The methods provided herein are highly N-terminal selective and are capable of yielding N-terminal mertansine conjugated polypeptides with site selectivity of 99% or greater.

Mertansine polypeptide conjugates

Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrins as catalyst provides high trans-selectivities (i.e., trans-:cis-epoxide ratio). A diversity of cycloalkenes bearing different allylic substituents are shown to be efficiently epoxidized to afford the corresponding trans-epoxides with excellent trans-selectivities (up to &#x3e;98%) and good yields (up to 99%). Acyclic allylic alkenes bearing different allylic substituents are efficiently epoxidized to afford the corresponding erythro-epoxides with good erythro-selectivities. The metalloporphyrin-catalyzed reactions exhibit up to 20 times higher trans-selectivities than the conventional method using m-chloroperoxybenzoic acid as oxidant. 

Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrin catalysts

Methods for effecting epoxidation of olefinic compounds using cyclic ketone catalysts is provided. In particular, catalytic asymmetric epoxidation of unfunctionalized olefins, e.g., trans-olefins and trisubstituted olefins using novel cyclic ketones possessing C.sub.2 symmetric chiral elements is provided.

Process for catalytic epoxidation of olefinic compounds, novel cyclic

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Hong Kong, China

Man-Kin Wong