Eisai Company, Limited

Mamoru Yanagimachi

Keigo Tanaka

Hironori Ikuta

Masashi Ito

Takao Saeki

Toshimi Okada

Daisuke Shinmyo

Hironobu Hiyoshi

Nobuyuki Kurusu

Nobuhisa Watanabe

Kazuki Miyazaki

Hiroyuki Sugumi

Seiji Yoshikawa

An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), Rrepresents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n is an integer of 0 to 2. Further, X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen atom, sulfur atom or oxygen atom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring. Also in the formula, CyA represents a 5- to 14 membered non-aromatic cyclic amino group or non-aromatic cyclic amido group which may be substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom. Finally, W represents a chain 

N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient

Quinuclidine compounds and drugs containing the same as the active ingredient

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Ibaraki, Japan

Mamoru Yanagimachi