Nippon Zeon Company, Ltd.

Mamoru Uchiyama

Yasuyoshi Chino

Yoshihiro Hayakawa

Shinichiro Tahara

Ryuji Nojiri

Hisatoyo Kato

Phosphoramidite compounds of the general formula ##STR1## wherein each of R.sub.1 and R.sub.2 represents a hydroxyl group having a protective group, or the group --OR.sub.4, R.sub.3 represents a hydrogen atom, a hydroxyl group having a protective group, or the group --OR.sub.4, R.sub.4 represents the group ##STR2## X represents a secondary amino group, R.sub.5 represents an allylic residue or a protective group capable of being split off by beta-cleavage, and B.sup.AOC represents a nucleoside base residue in which the amino or imino group is protected with an allyloxycarbonyl-type residue, with the proviso that only one of R.sub.1, R.sub.2 and R.sub.3 represents the group--OR.sub.4. The compounds can be produced by reacting a nucleoside represented by the general formula ##STR3## wherein each of R.sub.1 ' and R.sub.2 ' represents a hydroxyl group which may have a protective group, R.sub.3 ' represents a hydrogen atom, or a hydroxyl group which may have a protective group, and B.sup.AOC is as defined, with the proviso that only one of R.sub.1 ', R.sub.2 'and R.sub.3 ' is a hydroxyl group, with a phosphoramide compound represented by the general formula ##STR4## wherein X and R.sub.5 are as defined, and Y represents a secondary amino group or a halogen atom.

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Kawasaki, Japan

Mamoru Uchiyama