Ube Industries, Inc.

Mamoru Nakai

Keigo Nishihira

Shuji Tanaka

Teruhiko Inoue

Hiroshi Yoshida

Kozo Fujii

Hiroyuki Sawada

Tomio Kimura

Yoshiaki Kuroki

Tetsuo Omata

Noritada Iwamoto

Tokio Ohshima

Katsumasa Harada

Sumio Umemura

Fumio Iwata

Toshiharu Yamazaki

Kiyosi Oomori

Takuji Enomiya

Yoshikatsu Mori

A phenylacetone or its derivative having the general formula (I): ##STR1## wherein X, Y, and Z are independently a hydrogen atom, a hydroxyl group, a halogen atom, a nitro group, an amino group, a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 6 carbon atoms, or a benzyloxy group and any two substituents of X, Y, and Z may form, together with the benzene ring, a heterocycling ring having 5 to 7 members including 1 or 2 oxygen atoms is produced at a high yield and a high selectivity by reacting a 3-phenylpropylene or its derivative having the general formula (II): ##STR2## wherein X, Y, and Z are as defined above, with an alkyl nitrite having the general formula (III):

Process for producing phenylacetones

There is disclosed a process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine, which comprises subjecting a 2-alkyl-4-amino-5-formylpyrimidine to catalytic reaction with hydrogen and ammonia in the presence of a reduction catalyst. According to the process of this invention, the desired product can be obtained in much higher yield as compared with the processes known to the art.

Process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine

A process for the preparation of a urea derivative having the formula: ##STR1## in which A represents a straight- or branched-chain alkyl group having 1-20 carbon atoms, an aryl group, or a heterocyclic group, and each of R.sup.1 and R.sup.2 represents hydrogen, a straight- or branched-chain alkyl group having 1-20 carbon atoms, an alicyclic group, or an aryl groups, which comprises:

Process for the preparation of urea derivatives

Biochemical optical resolution of DL-tryptophans in which DL-tryptophan amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-Tryptophan amides in racemic DL-tryptophan amides are asymmetrically hydrolyzed to form optically active L-tryptophans at a high yield and almost all D-tryptophan amides remain without being subjected to hydrolysis. The resultant D-tryptophan amides are readily hydrolyzed, after separating L-tryptophans, to form optically active D-tryptophans at a high yield.

Process for preparing optically active tryptophans

A process for preparing a 4-amino-5-dialkoxymethylpyrimidine derivative of the formula: ##STR1## which comprises reacting a propanenitrile derivative represented by the formula (I) or the novel compound represented by formula (II): ##STR2## with an amidine of the formula: ##STR3## wherein R.sup.1 to R.sup.6 are as defined in the specification. Also disclosed is a process for making the novel compounds of formula (II).

Process for preparing 4-amino-5-dialkoxy-methylpyrimidine derivatives

Biochemical optical resolution of DL-tryptophanes in which DL-tryptophane amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-tryptophane amides in racemic DL-tryptophane amides are asymmetrically hydrolyzed to form optically active L-tryptophanes at a high yield and almost all D-tryptophane amides remain without being subjected to hydrolysis. The resultant D-tryptophane amides are readily hydrolyzed, after separating L-tryptophanes, to form optically active D-tryptophanes at a high yield.

Process for preparing optically active tryptophanes

There are disclosed a 4-alkoxy-1,3-dioxane-5-carbonitrile which is a novel compound represented by the formula ##STR1## wherein R represents a lower-alkyl group, and which is useful as an intermediate for the synthesis of Vitamin B.sub.1, and a process for preparing the novel compound by subjecting a 3-alkoxy-2-propenenitrile to reaction with a formaldehyde in the presence of an acid catalyst.

4-Alkoxy-1,3-dioxane-5-carbonitriles and process for preparing the same

There is provided a process for preparing a 5-amino-1,2,3-thiadiazole represented by the formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group or an aryl group, which comprises bringing a diazoacetonitrile represented by the formula ##STR2## wherein R has the same meaning as defined above, into contact with hydrogen sulfide in the presence of a base or with a salt of hydrogen sulfide, in a solvent.

Process for preparing 5-amino-1,2,3-thiadiazoles

A novel and industrial process for preparing cyclopentenone derivatives by heating C.sub.5 .about.C.sub.13 aliphatic acids having one substituent or intramolecular esters thereof in the presence of a solid acid catalyst in a good yield.

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Ube, Japan

Mamoru Nakai