Nippon Kayaku Kabushiki Kaisha

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Mamoru Kunishima

Hamao Umezawa

Tomio Takeuchi

Akira Matsuda

Yuya Nakayama

Akio Fujii

Yasuhiko Muraoka

Tomohisa Takita

Masahiko Yabuuchi

Minoru Masuda

Hiroaki Hamano

Kikuo Imazumi

Disclosed are an N-benzenesulfonyl derivative of cephamycin C represented by the following formula: ##STR1## which can easily be separated as a solid from an aqueous solution thereof, and a process for the preparation thereof. This derivative is valuable as an intermediate leading to a cephamycin type antibiotic substance.

Derivative of cephamycin C

Novel antibiotics cleomycins represented by the formula ##STR1## wherein R is a terminal amino residue of the cleomycin. These compounds are useful as a chemotherapeutic agent for treating cancer and bacterial infections.

Cleomycins and process for producing same

Anti-tumor low-toxicity coriolin derivatives represented by the following general formula: ##STR1## wherein one of X and Y is ##STR2## and the other is &gt;C OH, &gt;C.dbd.O or ##STR3##

Coriolin derivatives

Coriolin derivatives having antitumor activity and low toxicity represented by the following general formula: ##STR1## where R: --CO(CH.sub.2).sub.6 CH.sub.3 or --COCH(OH)(CH).sub.2).sub.5 CH.sub.3,

Coriolin derivatives and process for producing the same

Growing community of inventors

Tokorozawa, Japan

Mamoru Kunishima