Senju Pharmaceutical Co., Ltd.

Kyoto University

Mamiko Machida

Takeshi Nakajima

Yujiro Hayashi

Shinnosuke Machida

Norihiko Takeda

Tomoyo Miyabe

Masao Doi

Shuhei Yamada

A peptide fragment isolated from proline-rich protein 4 (PRP4) has a neuroprotective action. The peptide can be a neuroprotective drug in a preventive or alleviative pharmaceutical composition. The peptide can be used in a neuropathic treatment.

Neuroprotective peptide

A peptide which has a neuroprotective action, a neuroprotective drug and neuropathic treatment containing the peptide, and a preventive or alleviative pharmaceutical composition. The peptide comprises proline-rich protein 4 having the sequence of SEQ ID NO:1 or a partial sequence thereof, or a modified sequence thereof, which has a neuroprotective action.

The main object of the present invention is to provide a novel compound which has a VEGF receptor tyrosine kinase inhibitory activity and is useful as an active ingredient for the treatment of diseases accompanying angiogenesis or edema, for example, age-related macular degeneration or the like. The present invention includes, for example, an alkynyl indazole derivative represented by the following general formula (I), a pharmaceutical acceptable salt thereof, and a medicine containing thereof. 

Alkynyl indazole derivative and use thereof

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Osaka, Japan

Mamiko Machida