Meiji Seika Kabushiki Kaisha

Meiji Seika Kaisha, Ltd.

Meji Seika Kaisha Ltd.

Mami Kawaguchi

Yasuo Ohtsuka

Takashi Shishikura

Seiji Tsutsumi

Kenichi Fushihara

Takashi Tsuruoka

Sohjiro Shiokawa

Toshio Nishizuka

Hiroko Ogino

Yumiko Okada

Hideo Kitagawa

Toyoaki Ishikura

Sachiko Miyamoto

Hiromi Takata

Koji Tsuchiya

Takako Iwasaki

Keiko Shito

Megumi Imai

Maki Shiobara

Kiyoaki Katano

Eiki Shitara

Tomoaki Miura

Shokichi Ohuchi

Hiroyuki Iida

Masaro Shimizu

Kazue Yaegashi

Midori Ishikawa

Yasuko Isomura

Kenji Asai

Emiko Hatsushiba

Shigeru Hoshiko

Junko Tanaka

Kenichi Fusihara

Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereon. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein Rrepresents hydrogen, OH, alkyl or phenyl alkyl, 

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents

A process for preparing a compound represented by formula (IIa')wherein Q represents group (i) as defined in the specification and Rto R, R, R, and Rare as defined in the specification, by (1) reacting a compound represented by formula (V)wherein Rto Rand Rare as defined in the specification. with a compound represented by RRC&#x2550;O wherein Rand Rare as defined in the specification; (2) reacting the compound prepared in (1) with a compound represented by R&#x2014;C(&#x2550;O)&#x2014;Rwherein Rand Reach independently represent a chlorine atom, 4-nitrophenyl, or 1-imidazolyl; and (3) reacting the compound prepared in (2) with a compound represented by ROH wherein Ris as defined in the specification.

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic

Tricyclic benzazepine compounds

Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.

Triazole intermediates for tricyclic benzazepine and benzothiazepine

A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the agglutination of platelets is disclosed: ##STR1## wherein R.sup.1 represents a group --W--(CH.sub.2).sub.i --COOR.sup.3,

Compound with platelet aggregation inhibitor activity

Tricyclic benzazepine and benzothiazepine derivatives

Growing community of inventors

Kanagawa-ken, Japan

Mami Kawaguchi