Rutgers, the State University of New Jersey

Taxis Pharmaceuticals, Inc.

Malvika Kaul

Edmond Joseph LaVoie

Ajit S Parhi

Daniel S Pilch

Yongzheng Zhang

Gifty A Blankson

Ajit K Parhi

Liping Wang

Xiao Chen

Edmond J Lavoie

The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound: 

Antimicrobial agents

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I. 

Bacterial efflux pump inhibitors

The invention provides compounds of formula (I): wherein R-R, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.

The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of Xto Xare N and the remaining of Xto Xare CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. 

The invention provides compounds of formula (I): wherein R-Rand W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

The invention provides a compound of formula I: or a salt or prodrug thereof, wherein Y, W, Z, Z, Z, Z, Z, and R-Rhave any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.

The present invention provides compounds of formula I: formula (I) wherein X-Xand R-Rhave any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections. 

Growing community of inventors

New Brunswick, NJ, United States of America

Malvika Kaul