Fresenius Medical Care Deutschland Gmbh

Malte Gross

Andreas Maierhofer

Pascal Kopperschmidt

Alfred Gagel

Reiner Spickermann

Thomas Graf

Rainer Goldau

Michael Koch

Christoph Bardorz

Andreas Wuepper

Andreas Wüpper

A dialysis machine has at least one filter for the filtration of dialysis liquid and a device for determining calcification of the dialysis machine. The device has one or more sensors configured and arranged to detect either downstream, or upstream and downstream, of the at least one filter an ion concentration or a parameter representative of the ion concentration or of its change of the dialysis liquid, of a solution serving the decalcification or of another measuring solution. The device for determining the calcification of the dialysis machine has an evaluation or calcification unit configured to determine the calcification of the dialysis machine based on the ion concentration or parameter value detected by the sensor or sensors.

Dialysis machine, and method of determining the calcification in a dialysis machine

The invention relates to a device for reversing the blood flow for an extracorporeal blood treatment device, comprising an extracorporeal blood circuit (I), which includes an arterial blood line (A) leading from a patient to a blood treatment unit () and a venous blood line (A) leading from the blood treatment unit to the patient. Furthermore, the invention relates to an extracorporeal blood treatment device with a device for reversing the blood flow, and to a method for determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device according to the invention comprises two valve bodies () which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow according to the invention is characterized by a communication device () for receiving an electromagnetic high-frequency field from a read unit () of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

Device for reversing the blood flow for an extracorporeal blood treatment device and method for determining the reversal of the blood flow during an extracorporeal blood treatment

A method and a device for recognition of paravasal bleeding upon a supplying of blood to a vascular access via a line and/or upon the removal of blood from a vascular access via a line is provided. A device for extracorporeal blood treatment comprising a device for recognition of paravasal bleeding is also provided. The method and the device are based on the change of arterial pressure in the arterial branch or the venous pressure in the venous branch of the extra-corporeal circuit being registered during the extracorporeal blood treatment. One aspect of the method and the device is that pressure changes that come from a pressure level exhibiting a large difference from a reference value are more strongly considered than those that come from a pressure level that exhibits only a minor difference from the reference value.

Method and device for recognition of paravasal bleeding

A method of monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, that includes the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

Method and apparatus for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration, and/or peritoneal dialysis

A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

An apparatus and a method for the determination and regulation of the concentration of at least one dissolved substance in a fluid circuit, in which the fluid circuit includes at least two partial circuits separated by a filter in a semi-permeable manner, includes a detection unit for determining a concentration difference of at least one first dissolved substance, a determination unit for determining the influence of at least one second dissolved substance which is not identical to the at least one first dissolved substance, and a regulation unit for regulating the concentration of the at least one dissolved substance in the fluid circuit.

Device and method for determining and controlling the concentration of at least one solute in a fluid circuit

A dialysis liquid circuit with conduits for conducting dialysis liquid and elements for detecting air in the dialysis liquid. The elements includes at least one gas sensor traversed continuously by the dialysis liquid, which is configured such that it measures at least one property of the dialysis liquid which depends on the presence of air bubbles in the dialysis liquid, and which is arranged downstream of a region to be monitored of the dialysis liquid circuit. During operation of the dialysis liquid circuit a negative pressure exists with respect to atmospheric pressure, and the elements includes an evaluation unit which is connected with the gas sensor and which is configured such that the property measured by means of the gas sensor is evaluated with regard to the presence of air bubbles in the dialysis liquid.

Dialysis liquid circuit, dialysis apparatus comprising a dialysis liquid circuit, method for detecting air in a dialysis liquid flowing through a dialysis liquid circuit, and use of a gas sensor in a dialysis liquid circuit

A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.

Method and device for the detection of disruptions of the blood flow in an extracorporeal blood circuit

A blood purification device has a blood purification element divided into two chambers by a semipermeable membrane, with a first chamber as part of a dialysis fluid loop and a second chamber as part of an extracorporeal blood loop. By virtue of an analysis unit operatively connected to a sensor in the dialysis fluid loop, the device provides simple and uncomplicated determination of the blood purification performance of the blood purification element for a second material by derivation from a previously established blood purification performance for a first material. In this way, the device also determines the blood concentration of the second material during the blood treatment through measurements in the dialysis fluid without intervention in the treatment sequence.

Haemodialysis device

The invention relates to a method for determining the volume of distribution of a blood component in the body of a living organism, especially the volume of distribution of urea, during an extracorporeal blood treatment. According to this method, the blood to be treated flows through the blood chamber () of a dialysis machine () in an extracorporeal circuit, said dialysis machine being divided into said blood chamber and a dialysing liquid chamber () by a semipermeable membrane (). Dialysing liquid flows through the dialysing liquid chamber of the dialysis machine in a dialysing liquid channel. The method is based on the determination of the temporal change in the concentration of the blood component in the blood upstream of the dialysis machine using the temporal variation in a physical or chemical characteristic of the dialysing liquid upstream and downstream of the dialysis machine and the determination of the volume of distribution of the substance in the body of a living organism using the temporal variation in the concentration of the blood component in the blood. The invention also relates to a device for the extracorporeal blood treatment, comprising a device for determining the volume of distribution of a blood component in the body of a living organism.

Method for determining the distribution volume of a blood component during an extracorporeal blood treatment and device for carrying out the method

A method for determining a treatment parameter on a haemofiltration device, as well as a haemofiltration device for applying the method, based on the recognition that a determination method known from haemodialysis can, with little modification, be transferred to haemofiltration. To this effect a physical-chemical characteristic of the substitution fluid and of the fluid which is removed from the haemofilter by way of an ultrafiltrate outlet pipe, is determined. Furthermore, this characteristic is acquired before, after or during a change of this characteristic in the substitution fluid, and is evaluated. As a result, the ion dialysance and thus the urea clearance of a haemofiltration device, which can also be operated as a haemodiafiltration device, can be determined.

Method for determining a treatment parameter on a haemofiltration device, and haemofiltration device for applying the method

A method and a device for determining the efficiency of a dialyzer of a dialysis machine during a dialysis treatment wherein the dialyzer is divided by a semipermeable membrane into a blood chamber and a dialysis fluid chamber and wherein the blood flows at a predetermined flow rate through the blood chamber and dialysis fluid flows at a predetermined flow rate through the dialysis fluid chamber. In use, the dialysance or clearance for a predetermined dialysis fluid flow rate and/or blood flow rate is measured, and then the dialysance or clearance for any dialysis fluid flow rate and blood flow rate is calculated.

Method of determining the efficiency of a dialyzer of a dialysis machine and a dialysis machine for carrying out this method

A method and device for detecting stenoses in a tubular line system during an extracorporeal hemotherapy. The tubular line system has an arterial branch going out from the patient and leading to a hemotherapeutic unit, and a venous branch going out from the hemotherapeutic unit and leading to the patient, where an oscillating pressure signal is generated in the tubular line system, and the oscillating pressure signal is measured. To detect stenoses, the frequency spectrum of the oscillating pressure signal is analyzed, in response to a change in the frequency spectrum. This method is based on the principle that, in response to the existence of a stenosis, the dynamic performance of the tubular line system changes, the higher frequency components of the pressure signal generated by the rollers of the blood pump, which propagates across the tubular line system, being attenuated due to the compliance of the line system.

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Ulm, Germany

Malte Gross