The United States of America, As Represented by the Secretary, Department of Health and Human Services

Mallika Sastry

Baoshan Zhang

Michael Gordon Joyce

Yongping Yang

Ivelin Georgiev

Guillaume Stewart-Jones

Marie Pancera

Peter D Kwong

Barney S Graham

Man Chen

Cinque Soto

Tongqing Zhou

Gwo-Yu Chuang

Aliaksandr Druz

Jason Gorman

John R Mascola

Masaru Kanekiyo

Jason Scott McLellan

Jeffrey C Boyington

Wing-Pui Kong

Yaroslav Tsybovsky

Li Ou

Gilad Ofek

Ulrich Baxa

Paul Thomas

Joseph Van Galen

Lei Chen

Sanjay Srivatsan

Emily Rundlet

Cheng Cheng

John Mascola

Priyamvada Acharya

Rita Chen

Jason S Mclellan

Ivelin Stefanov Georgiev

Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

Prefusion RSV F proteins and their use

HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Recombinant HIV-1 envelope proteins and their use

Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

Substitutions-modified prefusion RSV F proteins and their use

Growing community of inventors

Rockville, MD, United States of America

Mallika Sastry