Takeda Pharmaceutical Company Limited

Cardurion Pharmaceuticals, LLC

Corvas International, Inc.

Dendreon Corporation

Mallareddy Komandla

John David Lawson

Joanne Miura

Lily Kwok

Joseph Edward Semple

Zacharia S Cheruvallath

Christopher McBride

Junya Shirai

Xiaolun Wang

Tomohiro Okawa

Nicholas Scorah

Keiko Kakegawa

Minoru Yoshida

John S Tyhonas

Terufumi Takagi

Mark Sabat

Phong H Vu

Yasufumi Miyamoto

Mingnam Tang

Akito Shibuya

Rei Okamoto

Zenyu Shiokawa

Yuta Tanaka

Haixia Wang

Yoichi Nishikawa

Nobuyuki Matsunaga

Yoshito Terao

Takafumi Yukawa

Takeshi Yoshikawa

Takashi Nakahata

Philip Erickson

Hiroki Takahagi

Paul Tanis

Jeffrey Alan Stafford

Michael Brennan Wallace

Jun Feng

Odile Esther Levy

Zhiyuan Zhang

Ofir Moreno

Jerome C Bressi

Sean Timothy Murphy

David Duncan

Scott Jeffrey Kemp

John Eugene Reiner

Shaosong Chu

Amir P Tamiz

Daniel Vanna Siev

Huong-Thu Ton-Nu

L Josue Alfaro-Lopez

Sanjib Das

Christopher Mcbride

The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification,or a salt thereof.

Substituted amines for treating cardiac diseases

The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein L, R, R, R, R, R, R, and Rare defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating obesity and related diseases, disorders, and conditions associated with MetAP2.

Substituted-1,4-dihydropyrazolo[4,3-b]indoles

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, and Rare defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating obesity and related diseases, disorders, and conditions associated with MetAP2.

Indazole derivatives

Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.

cMET inhibitors

The present invention provides matriptase inhibitors and compositions thereof useful for treating cancer. Martripase is a trypsin-like serine protease active in the development of cancerous conditions, such as tumors and metastasis of cancer.

Matriptase inhibitors and methods of use

The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and an optionally substituted heteroaryl group at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.

Non-convalent thrombin inhibitors

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Mallareddy Komandla