Harbor Branch Oceanographic Institution, Inc.

Malika Gunasekera

Sarath P Gunasekera

Ross E Longley

Neal S Burres

Peter J McCarthy

H Howard Sun

Sue S Cross

Frank Koehn

Novel sterol disulfates have been isolated from the marine sponge Petrosia weinbergii. These compounds, and derivatives thereof, are useful antiviral compounds. One of these compounds is active against the AIDS virus and exhibits immunosuppressive activity.

Sterol disulfates and methods of use

A novel lactam discodermide has been isolated from a marine sponge. This compound, and its derivatives, are useful as antifungal and antitumor agents.

Novel bioactive discodermides and methods of use

Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ,

Discodermolide compounds, compositions containing same and method of

Discodermolide compounds, compositions containing same and methods of

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Vero Beach, FL, United States of America

Malika Gunasekera