Metabasis Therapeutics, Inc.

Mali Venkat Reddy

Mark D Erion

Scott J Hecker

Qun Dang

Serge H Boyer

K Raja Reddy

Raja K Reddy

Brett C Bookser

Robert Huerta Lemus

Nicholas Brian Raffaele

Zhili Sun

Haiqing Li

Jorge E Gomez-Galeno

Matthew P Grote

Thanh Huu Nguyen

Paul D Van Poelje

William Craigo

Mingwei Chen

Jeff Stebbins

Serge Henri Boyer

Paul D Van Polje

Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co-crystals and prodrugs thereof. Formula I 

Glucagon antagonists

Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co-crystals and prodrugs thereof. 

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San Diego, CA, United States of America

Mali Venkat Reddy