Emory University

Li-cor, Inc.

Malgorzata Lipowska

Andrew Taylor

Luigi G Marzilli

Lyle R Middendorf

Gabor Patonay

Narasimhachari Narayanan

Lucjan Strekowski

Jeffrey Klenc

Lory Hansen

Andrew T Taylor, Jr

This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes compriseTc or Re. In certain embodiments, the ligands are substituted with a fluorine, a fluorine-18(F) radioisotope, or other radionuclide.

Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers

This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes compriseTc or Re. In certain embodiments, the ligands are substituted with a fluorine, a fluorine-18 (F) radioisotope, or other radionuclide.

This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracerTc(CO)(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure encompasses methods of imaging the kidneys and measuring effective renal plasma flow (ERPF) in an animal or human subject using renal scintigraphy, comprising administering to an animal or human subject an amount of a renal tracer, wherein the renal tracer comprisesTc-(CO)(NTA). Another aspect of the disclosure are methods of measuring effective renal plasma flow in an animal or human subject, comprising administering to an animal or human subject an amount of a renal tracer, wherein the renal tracer comprisesTc-(CO)(NTA), isolating a series of plasma samples from the animal or human subject after administering the renal tracer and quantitatively detecting the amount of the renal tracer in the biological samples.

Methods of determining renal function using technetium-99m tricarbonyl-nitrilotriacetic acid

The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a monothiourea (MTU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.

Metal chelates as pharmaceutical imaging agents, processes of making

The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a thioacetamidethiourea (TATU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.

To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

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Decatur, GA, United States of America

Malgorzata Lipowska