Glaxo Wellcome Inc.

Smithkline Beecham Corporation

Burroughs Wellcome Co.

Malcolm Stuart Nobbs

Richard M Hyde

Alistair A Miller

Michael John Leach

Brian Cox

Gita Punjabhai Shah

Dean David Edney

Michael Simon Loft

Mark Patrick Healy

Charanjit Bountra

Michael John

Sandra Jane Rodgers

Pyrazine compounds

The present invention relates to the use of sodium channel antagonists in the treatment of diseases mediated by, or exacerbated by, neuronal apoptosis, in particular sensory neuronal apoptosis.

Medical use

Triazine compounds for treatment of CNS disorders

A compound of formula (I) and pharmaceutically acceptable prodrugs, salts and solvates thereof.

A compound of formula (I) wherein R,is selected from the group consisting of phenyl substituted by one or more halogen atoms, naphthyl and naphthyl substituted by one or more halogen atoms; R,is selected from the group consisting of &mdash;NH,and &mdash;NHC(&boxH;O)R,; R,is selected from the group consisting of &mdash;NR,R,, &mdash;NHC(&boxH;O)R,and hydrogen, R,is selected from the group consisting of hydrogen, -C,alkyl, -C,alkyl substituted by one or more halogen atoms, &mdash;CN, &mdash;CH,OH, &mdash;CH,OR,and &mdash;CH,S(O),R,; wherein R,represents C,alkyl or C,cycloalkyl, and R,and R,, which may be the same or different, are selected from hydrogen and C,alkyl, or together with the nitrogen atom to which they are attached, form a,-membered nitrogen containing heterocycle, which heterocycle can be further susbtituted with one or more C,alkyl; R,is selected from C,alkyl or C,alkyl substituted by one or more halogen atoms; x is an integer zero, one or two; and pharmaceutically acceptable derivatives thereof; with the proviso that R,does not represent (a); when R,is &mdash;NH,, and both R,and R,are hydrogen.

Optically active phenyl pyrimidine derivatives as analgesic agent

A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.

Growing community of inventors

Stevenage, United Kingdom

Malcolm Stuart Nobbs