May & Baker, Ltd.

Malcolm P Toft

Garry Fenton

Neil Victor Harris

Christopher Smith

Michael J Ashton

David Riddell

Keith A Stuttle

Ian Michael McFarlane

David J Lythgoe

Andrew W Bridge

Christopher G Newton

Donald I Dron

Robert K Chambers

Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Isoquinolinones

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Romford, United Kingdom

Malcolm P Toft