Mcneil Ab

Ortho-mcneil Pharmaceutical Corp.

Ortho Pharmaceutical Corporation

Johnson & Johnson Consumer Companies, Inc.

Ncneilab, Inc.

Malcolm K Scott

Allen B Reitz

Pauline J Sanfilippo

Tina Morgan Ross

Louis J Fitzpatrick

Kevin Pan

Richard Cordova

Joseph Meschino

Daniel H S Lee

David Anthony Demeter

Cynthia Anne Maryanoff

Robert H Chen

Carlos Plata-Salaman

Hoau-Yan Wang

Frank John Villani, Jr

Chris R Rasmussen

Alfonzo D Jordan

Samuel O Nortey

C Royce Rasmussen

Frank J Villani, Jr

Anna Vavouyios-Smith

Haou-Yan Wang

This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure: 

Anti-inflammatory compounds

The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.

Method for treating neurodegenerative disorders

This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:

Method of treating neurodegenerative disorders via inhibition of amyloid beta peptide binding

The invention is directed to 1,4-dithiin- and 1,4-dithiepin-1,1,4,4-tetroxide derivatives useful as galanin receptor antagonists for treating disorders of the central nervous system. Pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions such as an eating disorder, obesity, bulimia nervosa, anorexia nervosa, binge eating, diabetes, dyslipidemia, hypertension, memory loss, sleep disturbances, pain, depression, anxiety, Alzheimer's disease, senile dementia, cerebral hemorrhage, or diarrhea are also described.

1,4-dithiin and 1,4-dithiepin-1,1,4,4, tetroxide derivatives useful as antagonists of the human galanin receptor

C-6 ring-substituted pyrido&lsqb;1,2-a&rsqb;benzimidazole derivatives useful in treating central nervous system disorders

A compound of the general formula 1; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.

S-heteroatom containing alkyl

Compounds of the general formula I ##STR1## are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I are also disclosed.

Cyclic benzylamino, benzylamido and benzylimido antipsychotic agents

Compounds of the general formula I ##STR1## are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I.

Imidazolidine antipsychotic agents

Compounds of the general formula I ##STR1## wherein A is N; Ar is aryl, substituted aryl or benzofuranyl, wherein the substituents are selected from C.sub.1 -C.sub.8 alkoxy; B is CO or CH.sub.2 and HET is selected from any of piperizine, piperidine, hexahydroazepine, morpholine, thiomorpholine or pyrrolidine, which may be substituted with one of more oxo groups are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I are also disclosed.

Thiophene and pyridine antipsychotic agents

Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents

Mannich bases of the formula (I): ##STR1## where X is oxygen or NR.sup.2, Alk is divalent alkyl, R.sup.1 is an aromatic ring, R.sup.2 is a substituent and the salts thereof. Useful as antipsychotic agents in man to be used in a manner similar to chlorpromazine.

1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or

Compounds of the following formula (I): ##STR1## wherein Alk is a straight or branched chain alkylene of about 1 to 12 carbons and R.sup.1 is a heterocyclic ring system, have been found to possess potent antisecretory activity and are thus useful in the treatment of hyperacidity.

Furan or thiophene derivatives of iminomethyl piperidines and use to

Heteroaromatic derivatives of iminomethyl piperidines and use to inhibit

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Lansdale, PA, United States of America

Malcolm K Scott