Pulmosonix Pty Ltd.

Malcolm Howard Wilkinson

Clive Andrew Ramsden

Philip John Berger

Frank Samuhel

Peter Camilleri

Jacqueline Anne Wilson

The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.

Method and apparatus for determining conditions of biological tissues

Airway monitoring apparatusincludes a driverfor applying sound in the audible frequency range to the airway of a subject and a detectorfor monitoring the response of the airway, e.g. by detecting transmitted sound signal components and/or reflected sound signal components. Variations in the detected sound signal, e.g. energy, due to attenuation of the signal, give an indication of the state of the airway, e.g. airway patency, and can be used to monitor sleep-disordered breathing events, such as apnea and hypopnea, and to provide a breathing event index, e.g. AHI. The apparatus may provide servo-control for a respiratory assist device, such as a positive airway pressure device, so as to provide an appropriate pressure level setting. It may allow for home use of such devices and for home titration. It may also assist in discriminating central and obstructive breathing events, and in providing a measure of airway resistance.

A method of measuring tissue mobility includes applying an oscillatory force to a region of tissue and measuring the velocity with which the tissue moves in response to the applied force. Tissue mobility is then determined by a ratio of the tissue velocity to the applied force.

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Forest Hill, Australia

Malcolm Howard Wilkinson