Malvern Panalytical Inc.

Malvern Instruments Limited

Malcolm Connah

Jason Cecil William Corbett

Kevin Mattison

Fraser McNeil-Watson

Robert Jack

David McKnight

Fraser Keith McNeil-Watson

In one general aspect, an electrophoretic measurement method is disclosed that includes providing a vessel that holds a dispersant, providing a first electrode immersed in the dispersant, and providing a second electrode immersed in the dispersant. A sample is placed at a location within the dispersant between the first and second electrodes with the sample being separated from the electrodes, an alternating electric field is applied across the electrodes, and the sample is illuminated with temporally coherent light. A frequency shift is detected in light from the step of illuminating that has interacted with the sample during the step of applying an alternating electric field, and a property of the sample is derived based on results of the step of detecting.

Laser doppler electrophoresis using a diffusion barrier

Methods and apparatus for measuring particle characteristics are disclosed. In one aspect, an amount of light arising from interaction between light and a suspended sample is detected simultaneously with the acquisition of a photon count from a different direction. At least one measure of particle characteristics can then be derived based at least in part on timing between information from the steps of acquiring and detecting.

Light scattering measurements using simultaneous detection

A method of, and apparatus for, automatically determining an electric charge&#x2014;related characteristic or derived parameter of particles in a dispersion or of a cell wall, comprises having a particle&#x2014;containing dispersion provided in a cell. The dispersion is illuminated with light from a light source and detecting from a detection volume light scattered from the particles. An electric field is applied to the dispersion at a first frequency of change of direction of the electric field and an electric field is subsequently applied to the dispersion at a second frequency of change of direction of the electric field. First signals detected from the scattered light when the first frequency electric field is applied are used to provide first values related to the velocity distribution of the particles. A second velocity related signal or value derived from scattered light during the time that the second frequency electric field is applied is used to modify the velocity distribution related values to produce a modified particle velocity-related distribution; and the first frequency is low enough to obtain an acceptable resolution of the distribution of particle velocity&#x2014;related values.

Mobility and effects arising from surface charge

Growing community of inventors

Worcestershire, United Kingdom

Malcolm Connah