Unversität Zürich

The University of Melbourne

Universitatsspital Basel

Malay Patra

Gilles Gasser

Robin Beat Gasser

Abdul Jabbar

Jeannine Hess

Thomas Leighton Mindt

Andreas Bauman

Thomas L Mindt

Robin B Gasser

The invention relates to octadentate ligands of a general formula R-D-X-D-X-D-X-D-E-R, wherein D is C(O)N(OH) or N(OH)C(O), pyrimidinone or pyridinone, each X independently of any other X is a saturated or partially unsaturated, substituted or unsubstituted linker comprising 8-11 atoms selected from any of N, C, O; Ris alkyl, cycloalkyl, arene, or heteroarene, E is a saturated or partially unsaturated, substituted or unsubstituted chain comprising 1-50 atoms and Ris a moiety capable of selectively binding to a biomolecule, or a nanoparticle. The invention further relates to complexes of the ligand, particularly radionuclides and their use in radioimmunotherapy and imaging.

Multidentate bifunctional chelating agents for radionuclide complexation in diagnostics and therapy

The invention relates to compounds characterized by a general formula (1), 

Organometallic 2-cyano-2-aminobenzoate-propyl derivates and their use as anthelmintics

The invention comprises a compound characterized by a general formula (1),  wherein X is a group described by a general formula &#x2014;K&#x2014;F&#x2014;K&#x2014;, wherein wherein Z is a group described by a general formula &#x2014;K&#x2014;F&#x2014;K&#x2014;, wherein wherein each OM is an organometallic compound independently selected from each other from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound and their use.

Bis-organometallic 2-amino-3-hydroxy-2-methylpropanenitrile derivatives for use as anthelmintics

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Cambridge, MA, United States of America

Malay Patra