Latvian Institute of Organic Synthesis

Jsc Grindeks

Grindeks, a Joint Stock Company

Akciju Sabiedriba "olainfarm"

Maksims Vorona

Ivars Kalvins

Maija Dambrova

Liga Zvejniece

Antons Lebedevs

Grigorijs Veinbergs

Aleksandrs Cernobrovijs

Ivars Kalvinsh

Ilmars Stonans

Aleksandrs Chernobrovijs

Grigory Veinberg

Baiba Svalbe

Edijs Vavers

Ilga Misane

Agnija Ievina

Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.

Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures

The present invention provides a method for regeneration of chiral 2,2'-cyclopropylidene-bis(oxazolines), such as (3&R,3&#x2032;aR,8aS,8&#x2032;aS)-2,2&#x2032;-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[1,2-d]-oxazole and (45,4&#x2032;5,5R,5&#x2032;R)-2,2&#x2032;-cyclopropylidenebis-4,5-diphenyldihydro-4,5-oxazole, used as a part of complex catalysts for e.g. stereoselective addition reactions, from the reaction mixtures, by selective sorption of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) on a sorbent, such as silica gel, isolation of the sorbent from reaction mixture, desorption of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) from the sorbent with suitable organic solvent and final recovery of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) from the organic solvent used for desorption process. Catalytic quality of recovered compounds does not differ from those in freshly prepared catalysts.

Regeneration of 2,2'-cyclopropylidene-bis (oxazolines)

The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.

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Riga, Latvia

Maksims Vorona