The State University of New York

University of California

Tambo, Inc.

Maksim Royzen

Jose Manuel Mejia Oneto

Nathan Yee

Sangeetha Srinivasan

Ethan Miller

Jochem Theodoor Van Herpt

Da-Ming Gou

Chun-Min Zeng

Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.

Bioorthogonal compositions

The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

TCO conjugates and methods for delivery of therapeutic agents

The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.

Processes for preparing functionalized cyclooctenes

Growing community of inventors

Albany, NY, United States of America

Maksim Royzen