Bostongene Corporation

Maksim Chelushkin

Alexander Bagaev

Aleksandr Zaitsev

Ekaterina Nuzhdina

Ravshan Ataullakhanov

Boris Shpak

Ilya Cheremushkin

Vladimir Zyrin

Daniiar Dyikanov

Natalia Miheecheva

Yaroslav Lozinsky

Natalia Mikheecheva

Alexandr Zaitsev

Described herein are various methods of collecting and processing of tumor and/or healthy tissue samples to extract nucleic acid and perform nucleic acid sequencing. Also described herein are various methods of processing nucleic acid sequencing data to remove bias from the nucleic acid sequencing data. Also described herein are various methods of evaluating the quality of nucleic acid sequence information. The identity and/or integrity of nucleic acid sequence data is evaluated prior to using the sequence information for subsequent analysis (for example for diagnostic, prognostic, or clinical purposes). The methods enable a subject, doctor, or user to characterize or classify various types of cancer precisely, and thereby determine a therapy or combination of therapies that may be effective to treat a cancer in a subject based on the precise characterization.

Techniques for bias correction in sequence data

Techniques for determining one or more cell composition percentages from expression data. The techniques include obtaining expression data for a biological sample, the biological sample previously obtained from a subject, the expression data including first expression data associated with a first set of genes associated with a first cell type; determining a first cell composition percentage for the first cell type using the expression data and one or more non-linear regression models including a first non-linear regression model, wherein the first cell composition percentage indicates an estimated percentage of cells of the first cell type in the biological sample, wherein determining the first cell composition percentage for the first cell type comprises: processing the first expression data with the first non-linear regression model to determine the first cell composition percentage for the first cell type; and outputting the first cell composition percentage.

Systems and methods for deconvolution of expression data

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Moscow, Russia

Maksim Chelushkin