Snow Brand Milk Products Co., Ltd.

Daiichi Pharmaceutical Co., Ltd.

Makoto Yoshihama

Masamichi Nakakoshi

Nobuo Miyata

Hidetoshi Takahashi

Shoji Nakayama

Koji Tamura

Yoshikazu Ikeda

Kiyoshi Isono

Kenichi Kimura

Junji Nakamura

Shinobu Kagami

Kousaku Takahashi

Ken-ichi Kimura

Rolf Wolfgang Hartmann

Shin Nomoto

Nobuaki Fujise

Nobuyoshi Honda

Tsutomu Hoshino

Hiroaki Takaoka

Yasushi Yamashita

Kohji Tamura

Bertil Wachall

Fumiko Kanou

Kazuhiko Kurosawa

Makoto Ubukata

Takeo Uchiyama

Makoto Ubutaka

Antibiotics RK-1061s having a novel chemical structure and a method of production thereof. They have a structural formula represented by general formula(I) wherein A represents Ror RCH(OR)CH. Rrepresents 3-methylglutaric acid residue and Rrepresents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genusand isolating RK-1061s from the culture.sp. SN-1061Ms (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.

Antibiotics RK-1061 and process for preparing the same

Dihydronaphthalene compounds have excellent 17&agr;-hydroxylase/C -lyase inhibiting activity, thromboxan A synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are useful as preventive and/or therapeutic agents for various male sex hormone- and female sex hormone-dependent diseases such as prostate cancer, prostatomegaly, masculinization, breast cancer, mastopathy, uterine cancer, endometriosis, and ovarian cancer, as well as myocardial infarction, angina pectoris, and bronchial asthma.

Dihydronaphthalene compounds

Antibiotics RK-1061s having a novel chemical structure and a method of production thereof. They have a structural formula represented by general formula(I) wherein A represents R or R CH(OR )CH . R represents 3-methylglutaric acid residue and R represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061s from the culture. Streptomyces sp. SN-1061Ms (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.

Benzofuranone derivatives and a method for producing them

Tetralone or benzopyranone derivatives and a method for producing them

Prolyl endopeptidase inhibitors SNA-115 and SNA-115T, and process for

A physiologically active compound HS-1 having the following chemical structure is disclosed. This compound is prepared by culturing Chromobacterium violaceum, adding tryptophan and diethyldithiocarbamate (diethyldithiocarbamic acid) to the culture broth for reacting with the cells for producing HS-1 in the cells, and collecting the compound from the culture broth. This novel compound possesses antitumor and antimicrobial activity, and is effective as an antitumor agent or an antimicrobial agent. ##STR1##

Physiologically active compound

A remedy for endometriosis comprising, as an active ingredient, 14.alpha.-hydroxy-4-androstene-3,6,17-trione or an ester derivative thereof, can effectively treat endometriosis by the strong aromatase-inhibitory activity without giving serious side effects.

Treatment of endometriosis

Novel 7.beta.-hydroxy-4-pregnene-3,20-dione derivatives are disclosed. The group of these compounds has possibility of being utilized as an intermediate for the synthesis of progesterone derivatives having ovulation-inhibiting activity. These compounds themselves have also cell differentiation activity for M1 cells.

Method for preparing 7.beta.-hydroxy-4-pregnene-3,20-dione derivatives

A process for the preparation in high yield of 14.alpha.-hydroxy-4-androstene-3,6,17-trione which has an aromatase inhibition activity and is useful as an antitumor agent, in which the 6.beta.-hydroxyl group of 6.beta., 14.alpha.-dihydroxy-4-androstene-3,17-dione is selectively oxidized with the aid of visible light energy.

Process for preparing 14-.alpha.-hydroxy-4-androstene-3,6,17-trione

Novel androst-4-ene-3,17-dione derivatives are disclosed. The group of these compounds has biological activities, in particular, the inhibiting activity on human placenta-derived estrogen-synthesizing enzyme. Therefore these compounds are expected to be utilized in the field of medical care, particularly as anticancer drugs.

Novel androst-4-ene-3,17-dione derivatives and method for preparing same

Novel 7 .beta.-hydroxy-4-pregnene-3,20-dione derivatives and method for

Growing community of inventors

Utsunomiya, Japan

Makoto Yoshihama