Other

Taisho Pharmaceutical Co., Ltd.

Fumi Sato

Sato, Fumie

Makoto Yagi

Naoya Ono

Fumie Sato

Tohru Tanami

Hideo Tanaka

Hitomi Hirano

Masakazu Sato

Tetsuya Yabuuchi

Tetsuo Takayama

Fumiyasu Shiozawa

Hironori Katakai

Tomomi Ota

Iwao Arai

Norikazu Takano

An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula &#x2014;SO&#x2014;, a group represented by Formula &#x2014;SO&#x2014;, or the like, Rrepresents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, Rrepresents a hydrogen atom or the like, Rrepresents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, Rrepresents an aryl group, Rrepresents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and Rrepresents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).

Triazole derivative

A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between S1P and its receptor Edg-1(S1P), and is useful as a pharmaceutical product. 

A prostaglandin derivative represented by Formula (I): wherein X is a halogen atom in the &#x3b1;- or &#x3b2;-substitution, Y is an ethylene group, a vinylene group or an ethynylene group, Ris a Ccycloalkyl group, a Ccycloalkyl group substituted with a Cstraight or branched chain alkyl group or a Ccycloalkylalkyl group, Ris a hydrogen atom or a CORgroup (Ris a hydrogen atom, a Cstraight or branched chain alkyl group or a Cstraight or branched chain alkenyl group), n is an integer of 1 to 4 and p is 0, 1 or 2,a pharmaceutically acceptable salt thereof or a hydrate thereof.

Prostaglandin derivatives

A method of treating atopy-evoked pruritic symptoms by administering a prostaglandin derivative.

Antipruritic agent

Prostaglandin E analogues

Prostaglandin E1 derivatives

Growing community of inventors

Tokyo, Japan

Makoto Yagi