Mect Corporation

Bridgestone Corporation

Mitsui Toatsu Chemicals, Incorporated

Makoto Tanaka

Tomoya Ogawa

Masaaki Numata

Mamoru Sugimoto

Kenkichi Tomita

Takayuki Ishii

Isao Suda

Nobuyuki Kibushi

Mariko Ishii

Ryoichi Osawa

Makiko Kasano

Tae Yasunaga

Naokazu Sugiyama

Junichi Yamagishi

Shoji Yoshimura

Keizo Akutagawa

Takatsugu Hashimoto

Kazuo Yagawa

Kazuo Hachiya

Masayoshi Ito

Akira Awaya

Yoshitaka Nagai

Shohei Shibayama

Hisashi Kobayashi

Hayao Abe

Yusaku Ishizuka

Shuji Fujita

Norihiro Shimada

Kenji Miyamoto

Masanori Kobayashiu

An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts, thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

Method for modulating the immune system

An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

Methods for inhibiting the chemotaxis of neutrophils

In a flame-retardant rubber tire comprising an outer rubber body portion consisting essentially of a tread rubber layer, a sidewall rubber layer extending inward from each side edge of the tread rubber layer toward the vicinity of a bead portion in radial direction and a rubber chafer layer arranged in the vicinity of the bead portion, a flame-retardant rubber composition having an oxygen index of not less than 19.8 but not more than 27.5 is disposed so as to amount at least 20% by weight of the tread rubber layer. Such rubber tires are used in electric vehicles, automobiles, airplanes and the like and have excellent self-extinguishing property and flame-delaying property without damaging other rubber properties.

Flame-retardant rubber tires

Anti-inflammatory agent

GM.sub.3 analogous compound (I) below: ##STR1## wherein one of R.sup.2 and R.sup.3 represents a neuramic acid group represented by general formula (V): ##STR2## R.sup.5 represents ##STR3## or hydrogen; R.sup.6 represents hydrogen or a ceramide group represented by general formula (VI): ##STR4##

GM.sub.3 analogous compound

A pneumatic radial tire comprises a tread divided into 4 to 5 ribs by 3 to 4 main wide grooves each extending circumferentially of the tire. In this tire, at least one row of sipes isolated from the main grooves in the axial direction of the tire and arranged at an approximately equal interval in the circumferential direction of the tire is arranged in only a second rib viewed from the outside in the axial direction of the tire.

Pneumatic radial tires having a tread including isolated sipes

Sialic acid derivative with active ester groups expressed with the formula [I] ##STR1## Where R.sup.1 denotes hydrogen or an acetyl group, R.sup.2 denotes hydrogen or a lower alkyl group, R.sup.3 denotes C.sub.2 H.sub.4, C.sub.3 H.sub.6 or C.sub.2 H.sub.2, R.sup.4 denotes an hydroxyl group, the residue left after removing hydrogen from the alcohol portion of the active ester or alkyloxycarbonyloxy group, AC denotes an acetyl group, Ph denotes an phenyl group, and X denotes oxygen or sulfur. This sialic acid derivative has high reactivity because it has active ester groups in the molecules and can be used as a raw material or intermediate for synthesis of various sialic acid derivatives.

Sialic acid derivative with active ester groups

A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

Sialic acid-bonded octapeptide and preparation thereof

Growing community of inventors

Higashimurayama, Japan

Makoto Tanaka