Nippon Shinyaku Company, Ltd.

Mitsubishi Chemical Industries Limited

Makoto Sugiyama

Yoji Ezure

Yoshiaki Yoshikuni

Shigeaki Maruo

Nobutoshi Ojima

Katsunori Miyazaki

Hiroshi Enomoto

Teruya Nakamura

Junzo Seki

Makio Kobayashi

Takayuki Ozaki

Iwao Morita

Yukio Fujita

Yoshihisa Shibata

Masashi Yamamoto

Kazuo Wagatsuma

Hiroshi Yamashita

Kiyotaka Konno

Hiroaki Munakata

Yohji Ezure

Makoto Tsurufuji

Shigeru Sato

Takashi Seto

Atsuhiko Okita

Manabu Itoh

A drug carrier useful for improved drug delivery upon administration comprising a fat or fatty emulsion as a core and a surface layer thereover wherein the core amounts to 30% to 65% and the surface layer amounts to 35% to 70%. The constituents of the core and surface layer are detailed together with the improved drug delivery obtained. The emulsion has a mean particle diameter less than 100 nm.

Drug carriers

The present invention relates to stabilizing agents for enzymes which comprises an enzyme stabilizing amount of an N-substituted moranoline derivative of the formula (III): ##STR1## wherein R.sup.1 is phenyl lower alkynyl, phenoxy lower alkenyl or phenoxy lower alkynyl, wherein the phenyl moiety is unsubstituted, or a glucose oligomer thereof.

Moranoline derivatives and their production and the use of moranoline

A method of preparing crystals of a glucosylmoranoline formula (III) ##STR1## wherein R is hydrogen or lower alkyl by fractional cyrstallizatin using a polar solvent and an arylsulfonic acid.

Method of manufacturing moranoline derivatives

2-amino-2-deoxy-D-mannitol is produced from a microorganism strain of the genus Streptomyces or a mutant strain thereof in improved yields and purity.

Method for manufacturing 2-amino-2-deoxy-D-mannitol

Compounds of formula I are useful in the prophylaxis or treatment of hyperglycemic symptoms ##STR1## wherein R is alkyl substituted by one or more hydroxy.

Glucosylmoranoline derivatives and use thereof for inhibiting increase

A compound of formula (I) ##STR1## wherein: B is a divalent substituted or unsubstituted, cyclic or acyclic, saturated or unsaturated hydrocarbon group;

Glucosylmoranoline derivatives

A method of preparing a molecular compound of glucosylmoranoline of the formula I ##STR1## with methanol, which comprises stirring an aqueous solution comprising (I) and other moranoline derivatives with methanol, whereupon crystals of the molecular compound of (I) with methanol are formed.

Phenylacetic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or ##STR2## wherein R.sup.5 is an alkyl group of 1-6 carbon atoms or an aryl group; R.sup.2 and R.sup.3 are independently hydrogen or an alkyl group of 1-4 carbon atoms; R.sup.4 is hydrogen or an alkyl group of 1-4 carbon atoms, have been found to possess immunomodulating activity.

Immunomodulating agent

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Kyoto, Japan

Makoto Sugiyama