Kowa Company Limited

Nissan Chemical Industries Limited

Makoto Suda

Seiichi Sato

Hiroyuki Ishiwata

Soichi Oda

Mototsugu Kabeya

Manabu Shibasaki

Hiroshi Nakao

Takao Nagoya

Yukio Hattori

Masami Shiratsuchi

Hiromichi Shigyo

Akio Iwasaki

Yushi Saino

Takashi Nakagawa

Yoichi Yamauchi

Michihisa Umetani

The present invention is directed to a preventive or therapeutic agent for a glomerular disease comprising as an active ingredient a compound represented by formula (1): or a salt thereof. The preventive or therapeutic agent for glomerular diseases is useful for preventing or treating a variety of glomerular diseases including chronic glomerular nephritis.

Therapeutic agent for glomerular disease

A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

Bis(5-aryl-2-pyridyl) derivatives

A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof:wherein A is a substituted or unsubstituted aromatic hydrocarbon group, and X is a substituent having one of the following formulas (2) to (4):wherein, in formula (2), Ris a hydrogen atom or a di(lower alkyl)amino(lower alkyl) group, and m is an integer of 1 or 2; in formula (3), Yand Yeach is a nitrogen atom or a CH group, and n is 0 or an integer of 1 to 6; in formula (4), Rand Reach is a hydrogen atom or a lower alkyl group, Z represents a single bond, a substituted methylene group, a substituted imino group, an oxygen atom or a cycloalkylene group, and p and q each is 0 or an integer of 1 to 6.

Bis(2-aryl-5-pyridyl) derivatives

Diamide compound and medicine containing the same

Cyclic amide compound

Diamide compounds and compositions containing the same

Cyclic amide compounds

Diamide compound and drugs containing the same

The present invention relates to compounds represented by the following general formula (1):

The present invention is directed to a cell adhesion inhibitory agent, cellular infiltration inhibitory agent, antiallergic agent, antiasthmatic agent, and antiphlogistic, which contains a compound of the following formula (1): ##STR1## wherein each of R.sup.1 through R.sup.6 represents H, a halogen atom, a hydroxyl group, a lower alkyl group, or a lower alkoxy group, m represents a number of 1 from 3 inclusive, and n represents 2 or 3.

Inhibitors for cell adhesion and cellular infiltration

A polypeptide having a specific amino acid sequence is described. Also described are a novel DNA coding the polypeptide, a recombinant plasmid containing the DNA, a transformant containing the recombinant plasmid, an anticoagulant containing the polypeptide as an effective ingredient, and a process for the production of the polypeptide.

Nucleic acids encoding human placental coagulation inhibitor (PCI)

A polypeptide having an amino acid sequence as shown in FIG. 1 and its preparation method are disclosed. A DNA fragment capable of coding CPBII polypeptide (human placenta-derived coagulation inhibitor) is first obtained from the human placental cDNA library by using a CPBII-specific antibody as a probe. Then, microorganism cells are transformed by the use of a recombinant plasmid incorporated with the DNA fragment, allowing the resultant transformant to express the CPBII gene, to finally obtain a CPBII-like polypeptide. The polypeptide of this invention exhibits strong anticoagulation activities, and useful for an active component of anticoagulation medicines and preventin in vivo blood coagulation.

Method of treatment using an anticoagulant polypeptide

Growing community of inventors

Tsukuba, Japan

Makoto Suda