Mitsubishi Pharma Corporation

National Institute of Health

Kyoritsu Seiyaku Corporation

Japan As Represented by the Director General of the Agency of National

Japan As Respresented by the Director General of the Agency of National

Japan As Represented by Director General of Agency of National Institute of Infectious Diseases

Makoto Seki

Tatsuo Miyamura

Yoshiharu Matsuura

Izumu Saito

Yoshikazu Honda

Toshiya Hamada

Kenyo Ishii

Seima Itami

Koji Kimura

Tatsurou Shibui

Yoshihisa Yotsumoto

Shuichi Matsuyama

The present invention provides a subcutaneous injection product for cattle for inducing superovulation characterized by comprising aluminum hydroxide gel and an efficient amount of a gonadotropin, wherein the concentration of the aluminum hydroxide is, in terms of the amount of aluminum, higher than or equal to 0.2 mg/mL and lower than 1.0 mg/mL, which is a subcutaneous injection product that is useful for producing good calves and that can induce superovulation in a cow by a single administration. The present invention also provides a method for producing good calves undergoing steps of subcutaneously injecting the aforementioned injection product into a cow to thereby induce superovulation, inducing estrus in the cow, conducting artificial insemination, and then collecting fertilized eggs.

Subcutaneous injection product for cattle for inducing superovulation

The present invention provides a substance which inhibits the binding between E2/NS1 protein of hepatitis C virus and a cell infectious with hepatitis C virus, a cell expressing CD81, or CD81. The present invention can provide a novel medicament which has an anti-viral effects such as an inhibitory action against HCV infection.

Remedies for hepatitis C

A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.

Method for producing ectoprotein of hepatitis C virus

Method of producing ectoprotein of hepatitis C virus

Growing community of inventors

Machida, Japan

Makoto Seki