Ube Industries, Inc.

Makoto Okudo

Noriaki Iwase

Tomio Kimura

Shigeru Ushiyama

Shigeyuki Kono

Hiroshi Nishida

Eiji Okanari

Masaaki Matoyama

Masaaki Ito

Hirofumi Matsunaga

Kenji Nishikawa

Hidetoshi Sunamoto

Yusuke Shiraishi

Yasuhiro Aga

Masahiro Kojima

Satoshi Umezaki

Sayaka Ogi

Takashi Matsushita

Kazuhiro Onuma

Masayuki Tanaka

Masahiko Hagihara

Tetsushi Katsube

Tomoko Kanda

Manabu Shigetomi

Takayuki Nakanishi

The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia), two R moieties each independently represent a Calkyl group or the like; and R, Rand Reach independently represent an optionally substituted linear or branched Calkyl group. 

Substituted dihydropyrrolopyrazole derivative

A novel &#x3b1;-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; Ris the same or different, and represents a halogen atom, or a C-Calkyl group; Rrepresents a hydrogen atom, or a C-Calkyl group; p represents an integer of 0 to 5; V represents CRwherein Rrepresents a hydrogen atom, an amino group, a nitro group, or a C-Calkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

Halogen-substituted heterocyclic compound

The invention provides a novel &#x3b1;-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament. The salt is represented by the general formula (I):  

Halogen-substituted heterocyclic compound salt

A novel &#x3b1;-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided.

The present invention discloses a pyrrolopyridazinone compound represented by the formula (1):  useful, for example, as an anti-inflammatory agent or an inhibitor of respiratory tract contraction.

Pyrrolopyridazinone compound

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Ube, Japan

Makoto Okudo