Toyo Boseki Kabushiki Kaisha

Makoto Ohno

Isamu Yamamoto

Hidehiko Sakurai

Mitsuru Suzuki

Morio Miyagi

Masaru Kanaizumi

Kimihiro Mabuchi

Tohru Uenishi

Shinya Koyama

Takafumi Hayashi

Motoki Kyo

Takahito Sagara

Tomohiro Kitagawa

Kazuhisa Shibata

The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module.

Hollow fiber membrane, method for manufacturing the same, and blood purification module

The present invention provides a plasma separation filter capable of easily, speedily and safely separating plasma from a small quantity of blood without damaging blood cell components in the blood. The plasma retains the same protein concentration as in the blood. The present invention also provides a method using such a filter and an apparatus comprising such a filter. The filter of the present invention comprises a micro fiber medium formed of micro fibers with an average hydraulic radius of 0.5 &mgr;m to 3.0 &mgr;m. Such a micro fiber medium is placed in a container having an inlet and an outlet so that a ratio (L/D) of a blood flow passage length (L) to a blood flow passage diameter (D) is 0.15 to 6. The present invention provides such a filter, a plasma separation method using the filter, and a plasma separation apparatus comprising the filter. The present invention can significantly contribute to promote the automation and enhance speediness and safety in clinical tests.

Plasma separation filter

A blood purification membrane having a membrane thickness of 10 to 35 .mu.m, an inner diameter of 100 to 300 .mu.m, a porosity of 50 to 85%, a water permeability (ultrafiltration rate) at 37.degree. C. of not less than 20 ml/m.sup.2 .multidot.Hr.multidot.mmHg and a sieving coefficient of albumin of not more than 0.01, a substantially homogeneous interior structure, and a smooth surface structure. A process for producing the membrane and a module are also provided.

Module for blood purification, blood purification membrane and its

A hollow fiber membrane made of a cellulose ester having a membrane thickness of not more than 75 .mu.m, and having void volume (x, % by volume) of the membrane and a rate of ultrafiltration (y, ml/m.sup.2.hr.mmHg) satisfying the following formula:

Cellulose ester hollow fiber membrane for plasma separation

A hollow fiber membrane of a cellulose ester for dialysis of body liquids, such as blood, and a method are described. The membrane, which has a membrane thickness of less than 20.mu., and a yield strength S.sub.b (g/filament) after heat-treatment at 80.degree. C. for 20 hours satisfies the following formula (I):

Method of making a hollow fiber membrane for dialysis

A hollow fiber membrane of a cellulose ester for dialysis which has a membrane thickness of less than 20.mu., and a yield strength S.sub.b (g/filament) after heat-treatment at 80.degree. C. for 20 hours satisfying the following formula (I):

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Otsu, Japan

Makoto Ohno