Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Kyowa Hakko Bio Co., Ltd.

Kyowa Hakko Kogyo K.k.

Kyowa Hakko Kogyo Kabushiki

Makoto Morimoto

Tadashi Ashizawa

Masaji Kasai

Hiromitsu Saito

Hiroshi Sano

Yutaka Kanda

Motoo Yamasaki

Kunikatsu Shirahata

Kazuo Yamaguchi

Eiji Kobayashi

Moriyuki Sato

Seiga Itoh

Yoshiharu Yokoo

Masami Okabe

Hiromasa Miyaji

Tetsuro Kuga

Motomichi Kono

Akira Sato

Yoshinori Komatsu

Yutaka Saito

Tadashi Hirata

Hajime Yoshida

Fusao Tomita

Yoichi Uosaki

Kazuhisa Fujimoto

Hirofumi Nakano

Shiro Akinaga

Isao Kawamoto

Tatsuya Tamaoki

Keiichi Takahashi

Isami Takahashi

Tokuyuki Kuroda

Kozo Asano

Shigeo Katsumata

Chikara Murakata

Akio Ishii

Katsushige Gomi

Katsuichi Shuto

Haruki Takai

Toru Yasuzawa

Hitoshi Arai

Takao Iida

Ikuo Matsukuma

Satoru Nagamura

Shinzo Ishii

Daisuke Machii

Youichi Uosaki

Iwao Kinoshita

Yasuo Onoda

Yuko Arai

Yasushi Shida

Koji Hisamura

Hideo Ueno

Yutaka Ohsawa

Tohru Sugaya

Michio Ichimura

Mitsuru Takahashi

Koji Yamada

Hiroshi Kase

Kenichi Mochida

Mitsunobu Hara

Nobuo Kosaka

Shigeru Kobayashi

Yukiteru Mimura

Noriaki Hirayama

Tatsuhiro Ogawa

Toru Sugaya

Tohru Yasuzawa

Yutaka Osawa

Hisayo Nomoto

Masanori Fukui

Yukou Arai

Kazuyuki Iwashashi

Kozo Asasno

Kenichi Muroi

Nobuo Kasaka

Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.

G-CSF conjugate

Method of producing a polypeptide having human granulocyte colony

Polypeptide derivatives of human granulocyte colony stimulating factor

DNA encoding human granulocyte colony stimulating factor plasmids and

A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.

Triphenylmethane derivatives

DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.

Pyrroloindole derivatives

Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.

DC-89 compounds and process for their preparation

A DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an anti-tumor agent.

DC-88A derivatives useful as antitumor agents

A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits born absorption inhibiting effects and is useful as a medicament for treating osteoporosis.

A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.

DC-88A derivatives

Novel pyrazoloacridone compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity.

6H-pyrazolo-[4,5,1-d,e]acridin-6-one derivatives having anit-tumor

Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.

DC-52 derivatives

Growing community of inventors

Shizuoka, Japan

Makoto Morimoto