Eisai R&d Management Co., Ltd.

Toshiba Silicone Co., Ltd.

Taiho Industries Co., Ltd.

Makoto Miyazaki

Tetsuo Kijima

Sachiko Yusa

Yoshihiro Arakawa

According to the present invention, there is provided a method for treating a motor neuron disease, comprising the step of administering a therapeutically effective amount of a compound having serotonin receptor antagonist activity or its pharmacologically acceptable salt or their solvate optionally together with a pharmaceutically acceptable carrier to a mammal for which the treatment of said disease is indicated.

Method for treating a motor neuron disease

A surface treating agent for coating vehicles comprises an amino group-containing polyorganosiloxane represented by the general formula (1) below, an organic acid, polydimethylsiloxane having a viscosity at 25.degree. C. of 5 to 300 cSt and an aqueous medium: ##STR1## wherein R is a monovalent hydrocarbyl group having a carbon number of 1 to 20, R.sup.1 is any of a monovalent hydrocarbyl group having a carbon number of 1 to 20, an alkoxy group having a carbon number of 1 to 6 or hydroxyl group, m is an integer of 10 to 1,000, n is an integer of 1 to 20, R each may be identical with or different from the other, and R.sup.1 each may also be identical with or different from the other, R.sup.2 is a substituent represented by the general formula (2) of: ##STR2## wherein R.sup.3 and R.sup.5 are a divalent hydrocarbyl group having a carbon number of 1 to 6, R.sup.4, R.sup.6 and R.sup.7 are hydrogen atom or a monovalent hydrocarbyl group having a carbon number of 1 to 20, r is an integer of 0 to 3, R.sup.3 and R.sup.5 may be identical with or different from each other, R.sup.4, R.sup.6 and R.sup.7 may also be identical with or different from one another.

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Kanagawa-ken, Japan

Makoto Miyazaki