Daiichi Sankyo Company, Limited

Makoto Michida

Masayuki Murakami

Yoshitaka Nakamura

Yuichi Aki

Kenichi Kimura

Daisuke Fukatsu

Takeshi Kaneda

Koji Hamaoka

It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme: wherein Rrepresents a C1-C6 alkyl group, Rrepresents a C1-C6 alkyl group, and Rrepresents a C1-C6 alkyl group.

Method for producing dicarboxylic acid compound

The problem to be solved is to provide a method for efficiently producing compounds (1) and (1a) that are important intermediate compounds in the production of FXa inhibitors (X) and (X-a). The solutions thereto are a method for producing a compound represented by the formula (8d) using a stereoselective intramolecular cyclization reaction, and a method for producing a compound (1f) or a salt thereof, or a hydrate thereof, which is characterized by desulfonylation of the compound (8d). In each formula, Rrepresents a C1-C6 alkyl group, a benzyl group, etc. 

Preparation method of optically active diamine compound

Growing community of inventors

Hiratsuka, Japan

Makoto Michida