The University of Texas System

University of Toronto

Makoto Kuro-o

Sachdev Singh Sidhu

Orson W Moe

Sarah L Barker

Johanne Pastor

Kevin P Rosenblatt

Yasushi Ogawa

Hiroshi Kurosu

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.

Antibodies that specifically bind alpha klotho

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a &#x3b1;Klotho polypeptide, optionally a folded &#x3b1;Klotho or optionally with a dissociation constant (K) of about 2 nM or less, as measured by competitive ELISA assay, methods of making and using to diagnose kidney diseases.

Nucleic acids encoding antibodies with high affinity for Alpha-Klotho

Antibodies which specifically bind &#x3b1;Klotho polypeptide

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a &#x3b1;Klotho polypeptide, optionally a folded &#x3b1;Kiotho or optionally with a dissociation constant (K) of about 2 nM or less, as measured by competitive ELISA assay, methods 0 of making and using to diagnose kidney diseases.

Antibodies with high affinity for alpha-Klotho

A method is provided to identify a modulator of &#x3b2;Klotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of &#x3b2;Klotho and an FGFR.

Growing community of inventors

Dallas, TX, United States of America

Makoto Kuro-o