Agency of Industrial Science and Technology

Other

Sumitomo Electric Industries, Limited

Kawasumi Laboratories. Inc.

Watanabe Pharmaceutical Industry Co., Ltd.

Makoto Kodama

Koichi Okita

Masuhiro Kogoma

Shigeru Asako

Keishiro Tsuda

Michio Abe

Sachiko Okazaki

Hiroaki Nomiyama

Tsukasa Sakai

Hiroshi Oinuma

Masaharu Komamiya

Tohru Maruyama

A plastic tube extruded from an extruder is conveyed through a plasma treatment apparatus. The plasma treatment apparatus is equipped with a tubular electrode body having a high-voltage side electrode and a grounded-side electrode disposed on a tubular insulator and a high frequency electric power source connected to the electrodes. When the plastic tube is conveyed through the electrode body with one end of the tube open to the atmosphere, a mixture of a glow discharge-stabilizing gas and a treating gas is fed into the other end of the tube and an alternating-current high-voltage is applied to generate a plasma region at a pressure near to atmospheric pressure in which the tube is treated with a glow discharge plasma. This method allows an interior and/or exterior surface of a plastic tube designed to convey a medical fluid to be continuously treated by a glow discharge plasma at atmospheric pressure to form an anti-thrombotic and blood-compatible film on the surface treated. The resulting surface-treated medical material can be produced at a comparatively low cost and maintains its original bulk material properties.

Method for producing medical materials

An antithrombogenic material is described, comprising an expanded polytetrafluoroethylene base having a collagen layer provided on the surface thereof, and further provided thereon a composite layer of collagen and a mucopolysaccharide, and said collagen is crosslinked with a crosslinking agent.

Antithrombogenic materials

Growing community of inventors

Tsukuba-ken, Japan

Makoto Kodama