Taiho Pharmaceutical Company Limited

Makoto Kitade

Shuichi Ohkubo

Chihoko Yoshimura

Yoshihiro Urade

Keiko Yamane

Kazuhiko Shigeno

Satoshi Yamashita

Katsunao Tanaka

Tetsuji Asao

Takao Uno

Takashi Mizutani

Hiromi Oshiumi

Hitomi Kondo

Atsushi Sato

Yuichi Kawai

Yasundo Yamazaki

Yuichi Hagiwara

Hiroyoshi Yamanaka

Shinichi Aoki

A pyrrolopyrimidine compound or a salt thereof and compositions, NAE inhibitors and anti-tumor agents containing the pyrrolopyrimidine compound or a salt thereof. The pyrrolopyrimidine compound or a salt thereof has an NAE inhibitory action and a cell growth inhibitory effect and is represented by Formula (A): 

Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein Xrepresents CH or N; any one of X, Xand Xrepresents N, and the others represent CH; any one or two of Y, Y, Yand Yrepresent C&#x2014;R, and the others are the same or different and represent CH or N; Rrepresents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; Rrepresents an alkyl group having 1 to 6 carbon atoms, or the like; and Rand Rrepresent &#x2014;CO&#x2014;Ror the like.

Azabicyclo compound and salt thereof

The present invention provides a piperidine compound represented by Formula (I) (wherein X, X, X, A, B and N are as defined in the Description); or a salt thereof.

Prostaglandin D synthase inhibitory piperidine compounds

The invention provides an indazole compound of formula (I) which is capable of inhibiting HSP90 and shows a cytostatic effect on cancer cells: 

Indole or indazole derivative or salt thereof

This invention relates to a piperazine compound represented by Formula (I), wherein

Piperazine compound capable of inhibiting prostaglandin D synthase

A novel bicyclic compound having an HSP90 inhibitory effect and a carcinostatic effect. A pharmaceutical agent based on the HSP90 inhibitory effect and useful in the prevention and/or treatment of a disease involving HSP90, particularly cancer. The compound has a general formula (I) or is a salt thereof wherein at least one of X, X, X, and Xrepresents N or N-oxide and the rest thereof are each independently C&#x2014;R; any one or two of Y, Y, Y, and Yrepresent C&#x2014;Rand the rest thereof are each independently CH or N; Rrepresents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O; Rrepresents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; Rrepresents a hydrogen atom, &#x2014;CO&#x2014;Retc. 

Bicyclic compound or salt thereof

This invention relates to a piperazine compound represented by Formula (I), 

The present invention provides a piperazine compound represented by Formula (I) or a salt thereof, wherein

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Hanno, Japan

Makoto Kitade