Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kogyo Co., Ltd.

Makoto Kigoshi

Hideki Morita

Eiji Hayakawa

Yasuki Kato

Yasuhiro Ishikawa

Jun Sugishita

Setsuko Yano

Takafumi Sato

Tomoaki Masada

Yasuhiko Ueno

Motohiro Ota

Akihiro Uchida

Kazutoshi Kuroda

Noboru Aoki

Toshiro Ochiai

Kazuki Asanome

It is an object of the present invention to provide an orally disintegrating tablet that has desirable oral disintegrability and excellent tablet hardness, a process for producing the same, and the like. The present invention provides an orally disintegrating tablet comprising:

Orally disintegrating tablet

An object of the present invention is to provide a composition improved in the solubility or oral absorbability. The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.

Composition improved in the solubility or oral absorbability

Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 &#x3bc;m; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 &#x3bc;m and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

Microcrystal

The present invention relates to a solid dispersion and a solid dispersion dosage form which comprise a xanthine derivative represented by the following formula (I) or a pharmacologically allowable salt thereof and a polymer.

Solid dispersion dosage form of amorphous xanthine derivative and enteric-coating polymer

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Sunto-gun, Japan

Makoto Kigoshi