Takeda Chemical Industries, Inc.

Makoto Kida

Kazuo Nakahama

Masayuki Muroi

Motowo Izawa

Seizi Igarasi

Masakazu Kikuchi

Takaki Hayakawa

A novel plasmid pATM3 is obtainable from a microorganism belonging to the genus Streptomyces. The plasmid pATM3 is useful as a cloning vector in recombinant DNA work.

Plasmid and production thereof

Macbecin derivatives are produced by bringing Macbecins into contact with a microorganism, or its processed matter, of the genus Streptomyces or Nocardia. The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent.

Macbecin derivatives

Antibiotic C-15003 PND of the formula: ##STR1## wherein R is H or alkanoyl containing not more than 5 carbon atoms is produced by contacting a maytansinoid compound with a culture broth, inclusive of a processed matter derived therefrom, of a microorganism belonging to one of the genera Streptomyces and Chainia which is able to transform said maytansinoid compound into Antibiotic C-15003 PND. Antibiotic C-15003 PND is useful as antitumor, antifungal or antiprotozoal agent.

Maytansinoid compound

Phosphoric acid esters of xylostasin, an intermediate for the synthesis of antibiotic deoxy-xylostasin or the like, are obtained by contacting xylostasin with cells or cell materials of microorganism belonging to the genus Escherichia or Pseudomonas which is resistant to xylostasin, in the presence of a phosphate donor.

Growing community of inventors

Kawanishi, Japan

Makoto Kida