Shionogi Company Limited

Makoto Kakinuma

Tetsuo Okada

Tsunetoshi Honma

Yoshiharu Hiramatsu

Haruo Koike

Kyozo Kawata

Yutaka Nishino

Toshiaki Masui

Katsuo Oda

Takayuki Kasai

A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein Rand Rare each independently C&#x2013;Calkyl.

Process for producing triterpene derivative

A process for producing amidine derivatives represented by the following reaction scheme, characterized in that the reactions of steps 1 and 3 are conducted in acetonitrile and the reaction of step 2 is conducted in acetone.

Process for preparation of amidine derivatives

A process for preparing a compound having PGD antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compound of the formula (III) or its reactive derivative, oxidizing the product with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls, reacting the product with an ylide under the conditions for Wittig reaction, and optionally deprotecting the product.

Process for preparing benzothiophenecarboxamide derivatives

Process for producing benzothiophenecarboxylic acid amide derivatives

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Kaizuka, Japan

Makoto Kakinuma