Sony Corporation

Taiyo Yuden Co., Ltd.

Matsushita Electric Industrial Co., Ltd.

Panasonic Corporation

Astellas Pharma Gmbh

Fujitsu Corporation

The Japan Research Institute, Limited

Id Pharma Co., Ltd.

Renesas Electronics Corporation

Koyo Seiko Company, Ltd.

Fujitsu Takamisawa Component Limited

Ip2ipo Innovations Limited

Bando Kagaku Kabushiki Kaisha

Tamura Kaken Co., Ltd.

Dna Vec Research Inc.

Makoto Inoue

Yoichiro Sako

Toshiro Terauchi

Masamichi Asukai

Takatoshi Nakamura

Katsuya Shirai

Motoyuki Takai

Yasushi Miyajima

Mitsuru Takehara

Kenichi Makino

Masafumi Matsuda

Akane Sano

Akihiro Komori

Satoshi Watanabe

Hiroshi Ito

Toru Sasaki

Kosei Yamashita

Yuichi Sakai

Hirofumi Tamori

Susumu Takatsuka

Hideo Nagai

Kenji Takahashi

Masanori Kobayashi

Yoshito Abe

Yuki Sawada

Shingo Yamasaki

Kozo Sawada

Takaari Uemoto

Mamoru Hasegawa

Koichi Yonezawa

Norihiro Nagai

Takeshi Saito

Masahiro Miki

Kentaro Sato

Mitsuhiko Nishimoto

Hiroshi Nohara

Akiko Inoue

Tsuyoshi Mizutani

Shunsuke Kakisaka

Norimitsu Kurihara

Ryo Takaoka

Masayoshi Miura

Kazuhiro Yokoyama

Susumu Yamaki

Yoshikazu Yonemitsu

Kiyotaka Sasanouchi

Hitoshi Iwasaki

Ken Watanabe

Yasuyuki Ueda

Hideyuki Sekine

Hisahiro Yasuda

Takeshi Kosaka

Hitoshi Ikuma

Kazuhiko Ohne

Mitsuaki Okumura

Jaeho Jeong

Hisao Hamaguchi

Naoyuki Tasaka

Shinichi Watarai

Susumu Nishimoto

Ryosuke Munakata

Naoto Kobayashi

Kiyohiro Samizu

Sachiko Tanaka

Hiroto Hara

Masao Igarashi

Hiroaki Tominaga

Lin Hong

Shigeharu Kondo

Tetsuo Matsuba

Katsunori Matsubara

Masaaki Ochi

Katsuyuki Mitomo

Akihiro Iida

Yasuji Ueda

Kenichiro Imamura

Shozo Furukawa

Kouji Oike

Hiroshi Ban

Yui Harada

Yasuhiro Shiina

Kentaro Hatanaka

Megumi Yasuda

Tsutomu Maeda

Genichi Matsuda

Tatsuhiro Taniwa

Koichi Saeki

Mitsuko Shuto

Tsugumine Shu

Keiji Ohyabu

Kosuke Suzuki

Stephen Hyde

Deborah Gill

Takashi Ogiyama

Shuichirou Kakimoto

Yasunori Kubota

Motohide Ikeda

Takahiro Hirata

An objective of the present invention is to provide an improved negative-strand RNA viral vector and a use thereof, the negative-strand RNA viral vector exhibiting transient high expression of genes loaded in the vector and enabling the rapid removal of the vector after said expression. It was discovered that by adding a micro-RNA target sequence to the NP, P, or L gene of a negative-strand RNA viral vector, it is possible to control the expression of the vector depending on the micro-RNA expressed by the introduction cell. In particular, when a micro-RNA target sequence was added to the NP or P gene, the expression of the vector decreased depending on the micro-RNA, and the removal of the vector was promoted, while the effect was reversed when a micro-RNA target sequence was added to the L gene. The vector can be applied in cell therapy and regenerative medicine and can be used as a therapeutic vector that targets cancer.

Paramyxovirus vector

The present invention provides donor polynucleotides formed by linking the two ends of a genomic fragment containing a cleavable site by a polynucleotide carrying a positive selection marker gene and a negative selection marker gene. Use of the donor polynucleotide makes it possible to modify only a target gene with avoiding the possibility of introducing mutations to sequences, called 'off-target', which are other than the target sequence, by introducing cleavage in a homologous site of the donor polynucleotide without introducing cleavage in a target gene locus.

Polynucleotide for modifying target sequence and use thereof

A filter includes first and second signal terminals, a filter circuit connected between the first and second signal terminals, a substrate having first and second surfaces, the first and second signal terminals being located on the first surface, a part of the filter circuit being located at a side of the second surface, a line located closer to the first surface than the filter circuit in the substrate, a first end of the line being connected to one of the first and second signal terminals, and a ground terminal that is located on the first surface and to which a second end of the line is connected, an area of a region where the line overlaps with the ground terminal being greater than an area of a region where the line overlaps with the one of the first and second signal terminals when the substrate is viewed in plan view.

Filter and multiplexer

A filter includes an input terminal, an output terminal, a ground terminal, a first capacitor and a second capacitor that are connected in series between the input terminal and the output terminal, a capacitive element that is connected in parallel to the first capacitor and the second capacitor between the input terminal and the output terminal, and has a Q factor that is smaller than a Q factor of the first capacitor and is smaller than a Q factor of the second capacitor, and an inductor that has a first end and a second end, the first end being coupled to a node that is provided between the first capacitor and the second capacitor and that is coupled to the capacitive element through the first capacitor and the second capacitor, the second end being coupled to the ground terminal.

A filter includes an input terminal, an output terminal, a first ground terminal, a second ground terminal, a first inductor having a first end coupled to a first node in a path between the input terminal and the output terminal and a second end coupled to a second node, a second inductor having a first end coupled to the second node and a second end coupled to the first ground terminal, and a third inductor having a first end coupled to the second node and a second end coupled to the second ground terminal.

A high-frequency device includes: a circuit substrate including dielectric layers that are stacked, wiring patterns located on at least one of the dielectric layers, and a passive element formed of at least one of the wiring patterns, the circuit substrate having a first surface that is a surface of an outermost dielectric layer in a stacking direction of the dielectric layers; a terminal for connecting the high-frequency device to an external circuit, the terminal being located on the first surface and electrically connected to the passive element through a first path in the circuit substrate; and an acoustic wave element located on the first surface and electrically connected to the passive element through a second path in the circuit substrate.

High-frequency device and multiplexer

In this invention, a non-infectious particle has been produced, comprising a pathogen antigen protein caused to be expressed on the surface of a virus particle having at least one species of paramyxovirus envelope protein missing from the particle. This particle has been found to hold within the particle a large amount of antigen protein compared to an infectious particle, and to be capable of eliciting a host immune response with extremely high efficiency. The non-infectious particle according to the present invention is useful as a vaccine against a pathogenic virus, or the like.

Infectious disease vaccine using non-infectious paramyxovirus particle

A filter includes: a substrate; input and output terminals located on the substrate; a resonant circuit located in a series pathway between the input and output terminals; a first component including a first inductor, which is electrically connected between a first node in the series pathway and a ground, and mounted in a first region on the substrate; a second component including a second inductor, which is electrically connected between a second node different from the first node in the series pathway and a ground, and mounted in a second region different from the first region on the substrate; and a third component including an acoustic wave resonator, which is electrically connected between a third node between the first and second nodes in the series pathway and a ground, and mounted in a third region between the first and second regions on the substrate.

A semiconductor device is provided which can detect a fluctuation of a power supply voltage. The semiconductor device includes a counter circuit that outputs a signal when a period during which a power supply voltage of a system to be monitored is lower than or equal to a first voltage value exceeds a predetermined time, a first flag circuit that sets a first flag based on the signal, a second flag circuit that sets a second flag when the power supply voltage becomes a second voltage value or lower, and a circuit that outputs a reset signal that resets the system when both the first and the second flags are set. The first voltage value and the second voltage value are higher than a minimum voltage that guarantees normal operation of the system. The first voltage value is higher than the second voltage value.

Semiconductor device

This invention relates to lentiviral gene transfer vectors pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. The present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as Cystic Fibrosis (CF).

Lentiviral vectors

A filter circuit includes: a first element that is a first capacitor or a first inductor connected in series between input and output terminals; a second element that is connected in parallel to the first element between the input and output terminals, is a second inductor when the first element is the first capacitor, and is a second capacitor when the first element is the first inductor; a third element that is connected in parallel to the first element and in series with the second element between the input and output terminals, is a third inductor when the first element is the first capacitor, and is a third capacitor when the first element is the first inductor; and an acoustic wave resonator having a first end coupled to a first node between the second element and the third element and a second end coupled to a ground terminal.

Filter circuit, multiplexer, and module

By allowing the movement of a user to affect the playback of content, the entertainment characteristic or uplifting spirits derived from content playback itself can be enhanced. The timing at which the user places his/her foot on the ground while walking or the timing at which the user shakes or changes from swinging in one direction to swinging to another direction is detected. Then, content, such as a music piece or moving pictures, is played back by allowing the timing of beats or bars of the music piece or the timing of scene changes or cut changes of the moving pictures to be synchronized with the timing of the movement of the user.

Content playback method and content playback apparatus

A communication method includes the steps of transmitting, by means of a first communication apparatus, personal information to a second communication apparatus; receiving, by means of the second communication apparatus, the personal information and searching, by means of the second communication apparatus, whether or not personal information having the same content as the received personal information exists in the second communication apparatus; and notifying, by means of the second communication apparatus, the first communication apparatus of a search result.

Communication method and apparatus

A sound-output-control device including an acquisition unit which acquires an anaerobic threshold, a reception unit which receives an input about exercise intensity, a calculation unit which calculates a value indicating a target heart rate of a user on the basis of the acquired anaerobic threshold and the received exercise-intensity input, a detection unit which detects a value indicating the current tempo of a physical exercise done by the user, and a control unit that controls a sound output on the basis of a result of a comparison of the target heart-rate value calculated by the calculation unit and the current physical-exercise-tempo value detected by the detection unit, so as to lead a heart rate of the user so that the heart rate of the user attains the target heart rate is provided.

Sound-output-control device, sound-output-control method, and sound-output-control program

Growing community of inventors

Tokyo, Japan

Makoto Inoue