Nihon Medi-physics Company, Limited

Makoto Azuma

Shigemi Seri

Hirohiko Yamauchi

Susumu Kondo

Kumiko Iwai

Jun Takahashi

Yuji Hashiguchi

Nobuo Ueda

Yoji Arata

Masaaki Hazue

Miki Kurami

Sakae Okano

A gadolinium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-.alpha.,.alpha.',.alpha.',.alpha.' '-tetrakis(methylacetic acid) or its salt, which is useful as a nuclear magnetic resonance imaging agent.

Method of NMR imaging

There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer of 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

Low molecular weight polysaccharide complexes for radiation diagnosis

There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer or 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

Low molecular weight polysaccharide complexes for X-ray imaging

Paramagnetic complexes of chelating compounds

Low molecular weight polysaccharide complexes for nuclear magnetic

There is disclosed a nuclear magnetic resonance imaging agent comprising a complex compound composed of (a) a dialdehyde-saccharide having a molecular weight of from 500 to 10,000, at least one of the constituent monosaccharides of which is oxidation-cleaved, (b) at least one complexing agent which is chemically coupled to an aldehyde group of the dialdehyde-saccharide and (c) a paramagnetic metal ion which is chemically coupled to the complexing agent.

Nuclear magnetic resonance imaging agent comprising a di-aldehyde complex

A compound of the formula II: ##STR1## wherein n is an integer of 2 to 10,

Diethylenetriamine pentaacetic acid derivatives

A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of:

Process for preparing a radiopharmaceutical composition

Chelating compounds and their use

A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.

Stable stannous chloride composition for labeling with radioactive

A compound of the formula II: ##STR1## wherein n is an integer of 2 to 10, A' is a bivalent linking group formed by reacting both the reactive groups of a cross linking reagent, and

A polyaminedithiol compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.11 and R.sub.12 are each a lower alkyl group, R.sub.21 is a hydrogen atom or a lower alkyl group, and R.sub.3 and R.sub.13 are each a hydrogen atom or a nitrogen-containing organic group, provided that at least one of R.sub.3 and R.sub.13 is a nitrogen-containing organic group, which is used for imaging of the regional cerebral blood flow.

Growing community of inventors

Chiba, Japan

Makoto Azuma