Columbia University

Makiko Suehiro

Koji Nakanishi

Kristian Stromgaard

Stine B Vogensen

The subject invention provides compounds having the structure: wherein Ris H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; Ris H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; Ris H or OH; Ris H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and wherein at least one of R, R, R, or Ris a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety, or an optically pure enantiomer of the compound or wherein R1 is H or OH; R2 is H, OH, halogen, unsubstituted or substituted, straight or branched (C-C) alkyl group, (C-C) alkenyl, or a (C-C) alkynyl, (C-C) alkoxy, (C-C) alkenyloxy, or (C-C) alkynyloxy, &#x2014;N3, &#x2014;COR5, &#x2014;CONR5R6, &#x2014;CO2R5, &#x2014;OCOR5, &#x2014;NH(OH), &#x2014;NR5R6, &#x2014;NHCOR5, &#x2014;N(OH)COR5, &#x2014;CH2OR5, &#x2014;OCH2CO2R5, &#x2014;CH2SR5, &#x2014;CH2NR5R6, &#x2014;SR5, &#x2014;OSR5, or &#x2014;NR5SO2R6, where R5 and R6 are each independently hydrogen, substituted or unsubstituted (C-C) alkyl, (C-C) alkenyl, or (C-C) alkynyl, or a cycloalkyl or aryl group having 3 to 10 carbon atoms; R3 is H or OH; R4 is H, (C1-C10) alkyl, (C1-C10) alkenyl, (C1-C10) alkynyl, -A-Ar, -A-Z-Ar, &#x2014;SO&#x2014;Ar, or -A-NR, or &#x2014;R, where A, Z and Ar are as defined herein, and the use of the compounds for detecting or identifying a receptor which binds the compounds of the invention or for treating a PAF associated condition in a subject.

[object Object]

The subject invention provides compounds having the structure: wherein Ris H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; Ris H, OH, a photoactivatable moiety, a fluorescent-moiety, or a radioactive moiety; Ris H or OH; Ris H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and wherein at least one of R, R, R, or Ris a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety, or an optically pure enantiomer of the compound or wherein R1 is H or OH; R2 is H, OH, halogen, unsubstituted or substituted, straight or branched (C&#x2013;C) alkyl group, (C&#x2013;C) alkenyl, or a (C&#x2013;C) alkynyl, (C&#x2013;C) alkoxy, (C&#x2013;C) alkenyloxy, or (C&#x2013;C) alkynyloxy, &#x2014;N3, &#x2014;COR5, &#x2014;CONR5R6, &#x2014;CO2R5, &#x2014;OCOR5, &#x2014;NH(OH), &#x2014;NR5R6, &#x2014;NHCOR5, &#x2014;N(OH)COR5, &#x2014;CH2OR5, &#x2014;OCH2CO2R5, &#x2014;CH2SR5, &#x2014;CH2NR5R6, &#x2014;SR5, &#x2014;OSR5, or &#x2014;NR5SO2R6, where R5 and R6 are each independently hydrogen, substituted or unsubstituted (C&#x2013;C) alkyl, (C&#x2013;C) alkenyl, or (C&#x2013;C) alkynyl, or a cycloalkyl or aryl group having 3 to 10 carbon atoms; R3 is H or OH; R4 is H, (C1&#x2013;C10) alkyl, (C1&#x2013;C10) alkenyl, (C1&#x2013;C10) alkynyl, -A-Ar, -A-Z-Ar, &#x2014;SO&#x2014;Ar, or -A-NR, or &#x2014;R, where A, Z and Ar are as defined herein, and the use of the compounds for detecting or identifying a receptor which binds the compounds of the invention or for treating a PAF associated condition in a subject.

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White Plains, NY, United States of America

Makiko Suehiro