Massachusetts Institute of Technology

National University of Singapore

Nanyang Technological University

Majid Ebrahimi Warkiani

Jongyoon Han

Chwee Teck Lim

Guofeng Guan

Haiqing Gong

Lidan Wu

Kah Ping Andy Tay

A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.

System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion

This invention relates to a multilayer filter. The filter comprises at least a first layer comprising a plurality of openings and at least a second permeable layer overlaying the first layer and reducing the size of the openings. The filter may further comprise one or more successive layers overlaying the second layer, wherein each layer further successively reduces the size of the openings. The filter may be used for separation of particles from fluid or gas. There is also provided a method for fabricating a multilayer filter.

Multilayer filter

Growing community of inventors

Singapore, Singapore

Majid Ebrahimi Warkiani