Clsn Laboratories, Inc.

Egen, Inc.

Majed Matar

Jason Fewell

Khursheed Anwer

Gregory Slobodkin

Danny H Lewis

Brian Jeffery Sparks

Richard Congo

Jennifer Rice

Jason G Fewell

Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.

Nucleic acid-lipopolymer compositions

Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.

Immuno gene therapy for treatment of cancer and hyperproliferative diseases

Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.

Polyamine derivatives

Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases

A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof

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Madison, AL, United States of America

Majed Matar