Galapagos Nv

E-therapeutics Plc

Maja Roscic

Christel Jeanne Marie Menet

Oscar Mammoliti

Javier Blanc

Mislav Orsulic

Dinko Ziher

Tanja Poljak

Filip Kolundzic

Srinivasamurthy Vadlamudi

Colin Stubberfield

There are described compounds of formula (I): and there use as a medicament in the treatment of conditions involving abnormal activation and/or malfunction of the of the hedgehog pathway, such as cancer, fibrosis and chronic graft-versus-host disease (cGVHD). 

Modulators of hedgehog (Hh) signaling pathway

The present invention discloses compounds according to Formula I: wherein Cy, R, L, R, R, R, L, and Rare as defined herein. Novel benzimidazoles according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons.

Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

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Zagreb, Croatia

Maja Roscic