Albert Einstein College of Medicine

Massachusetts Institute of Technology

Montefiore Medical Center

Maja H Oktay

John S Condeelis

Frank B Gertler

David Entenberg

Christopher Boyce Burge

Irina M Shapiro

Wu Albert Cheng

Joan Jones

Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using Tie-2 inhibitors. Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using inhibitors of Mena expression and/or function are also provided.

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism

A combination of markers (TMEM, MenaCalc, and MenalNV) for hematogenous metastatic cancer and their use for diagnosis, prognosis and predictive performance are disclosed.

Combined markers for metastatic cancer and uses thereof

Method for treating neoadjuvant chemotherapy-induced metastasis

The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.

Alternatively spliced mRNA isoforms as prognostic indicators for metastatic cancer

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Rye, NY, United States of America

Maja H Oktay