Johns Hopkins University

Mairead E Bartlett

Reid E Messersmith

Christopher M Hoffman, Jr

Scott A Shuler

Brian M Koronkiewicz

A microcapsule for use with an underwater adhesive includes a shell including nanoclay platelets and a polyurea product of an interfacial polymerization of a polyamine and an aromatic polyisocyanate. The microcapsule further includes a core composition encapsulated by the shell. The core composition includes a base catalyst for formation of a polyurethane, a polyol, and a hydrophilic solvent.

Microcapsules for use with polyurethane and epoxy adhesives

A bifunctional linker of Formula 1 wherein in Formula I, at least one of Rto Ris —COORand Ris —C-Calkyl(C-Calkynyl) or —C-Calkyl-C-Calkenyl(C-Calkynyl), preferably a terminal alkynyl. The bifunctional linker is used in a cycloaddition to tether two entities, for example a protein or antibody, and an active agent, to form a bisconjugate. The bifunctional linker also be used to form a conjugate, followed by cycloaddition in the presence of a comonomer composition to form a bisconjugate including a protein or antibody linked to an adhesive polymer network. Catalysis can be provided by a copper-containing paint on a surface to adhere the bisconjugate to the surface. Methods of synthesis and use of the bisconjugates imaging, diagnostic, and therapeutic applications are also described.

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Takoma Park, MD, United States of America

Mairead E Bartlett